DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair (Q48506341)

12 February 2018

title

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair (English)

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12 February 2018

author

David B Ascher

3

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12 February 2018

Tom Blundell

4

object named as

Tom L Blundell

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12 February 2018

Dimitri Y Chirgadze

2

object named as

Dimitri Y Chirgadze

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12 February 2018

author name string

Bancinyane L Sibanda

1

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12 February 2018

language of work or name

English

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publication date

2 February 2017

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12 February 2018

published in

Science

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12 February 2018

volume

355

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12 February 2018

issue

6324

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12 February 2018

page(s)

520-524

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12 February 2018

https://api.crossref.org/works/10.1126%2FSCIENCE.AAK9654

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Molecular views of recombination proteins and their control

21 January 2018

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Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

21 January 2018

1 reference

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

21 January 2018

1 reference

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N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.

21 January 2018

1 reference

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The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

21 January 2018

1 reference

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Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

21 January 2018

1 reference

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Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

21 January 2018

1 reference

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Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase

21 January 2018

1 reference

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Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

21 January 2018

1 reference

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Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

21 January 2018

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Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding

21 January 2018

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mTOR kinase structure, mechanism and regulation

21 January 2018

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The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability

21 January 2018

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CryoEM and image sorting for flexible protein/DNA complexes

21 January 2018

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Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

21 January 2018

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DNA-PKcs deficiency in human: long predicted, finally found.

21 January 2018

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Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

21 January 2018

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The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR)

21 January 2018

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Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions

21 January 2018

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BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle

21 January 2018

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The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends

21 January 2018

1 reference

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Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

21 January 2018

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Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs

21 January 2018

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

21 January 2018

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The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

21 January 2018

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Multi-crystal anomalous diffraction for low-resolution macromolecular phasing.

21 January 2018

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21 January 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

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Rapid model building of alpha-helices in electron-density maps

21 January 2018

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Features and development of Coot

21 January 2018

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Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities

21 January 2018

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Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

21 January 2018

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VADAR: a web server for quantitative evaluation of protein structure quality

21 January 2018

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A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

21 January 2018

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A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

21 January 2018

1 reference

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Identification of four highly conserved regions in DNA-PKcs.

21 January 2018

1 reference

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

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Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAK9654

1 reference

12 February 2018

1 reference

12 February 2018