Insights into the stereospecificity of ketoreduction in a modular polyketide synthase (Q48530570)

12 February 2018

title

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase (English)

1 reference

12 February 2018

author

Frank Schulz

4

1 reference

12 February 2018

Peter Leadlay

5

1 reference

12 February 2018

Manuela Tosin

object named as

Manuela Tosin

2

0 references

author name string

David H Kwan

1

1 reference

12 February 2018

Nadin Schläger

3

1 reference

12 February 2018

publication date

21 February 2011

1 reference

12 February 2018

Organic and Biomolecular Chemistry

published in

1 reference

12 February 2018

volume

9

1 reference

12 February 2018

issue

7

1 reference

12 February 2018

page(s)

2053-2056

1 reference

12 February 2018

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

The type I fatty acid and polyketide synthases: a tale of two megasynthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

The biosynthetic logic of polyketide diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

A tylosin ketoreductase reveals how chirality is determined in polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

The biochemical basis for stereochemical control in polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

A polylinker approach to reductive loop swaps in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

Structure-based dissociation of a type I polyketide synthase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1OB00022E

21 January 2018

Identifiers

DOI

10.1039/C1OB00022E

1 reference

12 February 2018

1 reference

12 February 2018