Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. (Q48575837)

http://europepmc.org/abstract/MED/17687047

12 February 2018

title

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. (English)

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http://europepmc.org/abstract/MED/17687047

12 February 2018

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3

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16 May 2020

Chi Him Eddie Ma

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16 May 2020

author name string

Robert S Griffin

1

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16 May 2020

Michael Costigan

2

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16 May 2020

Joachim Scholz

5

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16 May 2020

Andrew Moss

6

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Andrew J Allchorne

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Gregory L Stahl

8

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Clifford J Woolf

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16 May 2020

language of work or name

English

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publication date

1 August 2007

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http://europepmc.org/abstract/MED/17687047

12 February 2018

published in

Journal of Neuroscience

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volume

27

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16 May 2020

page(s)

8699-8708

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16 May 2020

issue

32

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Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

16 May 2020

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Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain.

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Glial activation: a driving force for pathological pain

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Extrahepatic synthesis of complement proteins in inflammation

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Transcriptional channelopathies: an emerging class of disorders

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Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment

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Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.

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Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases

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Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

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Analysis of gene expression in the developing mouse retina

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Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease

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p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

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Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection

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Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2

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Statistical significance for genomewide studies

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"Eat me" and "don't eat me" signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

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12 December 2020

Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines

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12 December 2020

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

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12 December 2020

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

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12 December 2020

Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations

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12 December 2020

C5a-induced gene expression in human umbilical vein endothelial cells

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12 December 2020

Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia

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12 December 2020

Descending modulation of pain

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12 December 2020

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

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12 December 2020

Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.

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12 December 2020

Do central terminals of intact myelinated primary afferents sprout into the superficial dorsal horn of rat spinal cord after injury to a neighboring peripheral nerve?

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12 December 2020

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

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12 December 2020

Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons

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12 December 2020

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

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12 December 2020

The complement system in regulation of adaptive immunity

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Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia

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Role of C5a in inflammatory responses

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12 December 2020

Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization

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12 December 2020

Recombinant rat IL-1beta and IL-6 synergistically enhance C3 mRNA levels and complement component C3 secretion by H-35 rat hepatoma cells

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12 December 2020

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

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12 December 2020

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

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12 December 2020

Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38.

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12 December 2020

Novel biological networks modulated by complement

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12 December 2020

Role of the immune system in chronic pain.

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12 December 2020

Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury.

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12 December 2020

Quantitative somatosensory thermotest. A key method for functional evaluation of small calibre afferent channels

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12 December 2020

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

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12 December 2020

Blockade of the complement C5a receptor reduces incisional allodynia, edema, and cytokine expression

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12 December 2020

Differential Spinal Cord Gene Expression in Rodent Models of Radicular and Neuropathic Pain

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12 December 2020

Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury.

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12 December 2020

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

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12 December 2020

C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion

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12 December 2020

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

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Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg.

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Sensory functions in chronic neuralgia

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12 December 2020

Complement activation by isolated myelin: activation of the classical pathway in the absence of myelin-specific antibodies

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12 December 2020

Changes in neuronal markers in a mononeuropathic rat model relationship between neuropeptide Y, pre-emptive drug treatment and long-term mechanical hyperalgesia.

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12 December 2020

Animal models for complement deficiencies

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12 December 2020

A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

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12 December 2020

Parapinopsin, a novel catfish opsin localized to the parapineal organ, defines a new gene family.

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12 December 2020

Experimental diffuse axonal injury induces enhanced neuronal C5a receptor mRNA expression in rats.

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12 December 2020

Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection.

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12 December 2020

Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain.

1 reference

12 December 2020

10.1523/JNEUROSCI.2018-07.2007

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672952&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6672952&resulttype=core&format=json

16 May 2020

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