The Na+/H+ exchanger-1 inhibitor cariporide prevents glutamate-induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload. (Q48614262)

13 February 2018

title

The Na+/H+ exchanger-1 inhibitor cariporide prevents glutamate-induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload. (English)

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author name string

Bo Kyung Lee

series ordinal

1

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Yi-Sook Jung

series ordinal

2

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publication date

1 April 2012

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Journal of Neuroscience Research

published in

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volume

90

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issue

4

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page(s)

860-869

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Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes

cites work

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Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

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Excitotoxic cell death

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alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta

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Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia

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Mitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A.

21 January 2018

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The regulation of reactive oxygen species production during programmed cell death

21 January 2018

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Cariporide (HOE642), a Selective Na + -H + Exchange Inhibitor, Inhibits the Mitochondrial Death Pathway

21 January 2018

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Selective loading of Rhod 2 into mitochondria shows mitochondrial Ca2+ transients during the contractile cycle in adult rabbit cardiac myocytes.

21 January 2018

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Ca2+-induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I.

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Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia

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Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates

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21 January 2018

Identifiers

DOI

10.1002/JNR.22818

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