Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation (Q48676930)

14 February 2018

http://europepmc.org/abstract/MED/24995673

title

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation (English)

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14 February 2018

http://europepmc.org/abstract/MED/24995673

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2

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11 June 2020

Albert D. Windhorst

10

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11 June 2020

Bieneke Janssen

1

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11 June 2020

Adriaan A Lammertsma

9

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11 June 2020

5

Robert C Schuit

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11 June 2020

3

Uta Funke

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11 June 2020

8

Lars R Perk

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11 June 2020

6

Esther Kooijman

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11 June 2020

7

Marissa Rongen

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11 June 2020

author name string

Arnold Spaans

4

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11 June 2020

publication date

1 June 2014

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14 February 2018

http://europepmc.org/abstract/MED/24995673

published in

Journal of Labelled Compounds and Radiopharmaceuticals

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11 June 2020

volume

57

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11 June 2020

issue

8

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11 June 2020

page(s)

509-516

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Mechanisms underlying inflammation in neurodegeneration

11 June 2020

cites work

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Microglia: proliferation and activation driven by the P2X7 receptor

21 January 2018

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P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases

21 January 2018

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COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord

21 January 2018

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Noninvasive molecular imaging of neuroinflammation

21 January 2018

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Purinergic systems, neuropathic pain and the role of microglia

21 January 2018

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The physiology, pharmacology and future of P2X7 as an analgesic drug target: hype or promise?

21 January 2018

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21 January 2018

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P2X purinergic receptor ligands: recently patented compounds

21 January 2018

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A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat

21 January 2018

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Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain

21 January 2018

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An extremely stable and orthogonal DNA base pair with a simplified three-carbon backbone

21 January 2018

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Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.

21 January 2018

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Synthesis and preclinical evaluation of novel PET probes for P-glycoprotein function and expression.

21 January 2018

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Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

21 January 2018

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Radiosynthesis of PET radiotracer as a prodrug for imaging group II metabotropic glutamate receptors in vivo

21 January 2018

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Synthesis, in silico, in vitro, and in vivo investigation of 5-[¹¹C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2.

21 January 2018

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Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat.

21 January 2018

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Characterization with [3H]quisqualate of group I metabotropic glutamate receptor subtype in rat central and peripheral excitable tissues

21 January 2018

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ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies

21 January 2018

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