Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. (Q48679489)

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3 November 2019

title

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis (English)

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3 November 2019

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5

M P Mattson

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3 November 2019

author name string

I Kruman

1

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3 November 2019

A J Bruce-Keller

2

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3 November 2019

D Bredesen

3

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3 November 2019

G Waeg

4

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3 November 2019

language of work or name

English

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publication date

1 July 1997

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3 November 2019

published in

Journal of Neuroscience

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3 November 2019

volume

17

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3 November 2019

issue

13

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3 November 2019

page(s)

5089-5100

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Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

3 November 2019

cites work

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4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes.

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Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration.

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Michael addition-type 4-hydroxy-2-nonenal adducts in modified low-density lipoproteins: markers for atherosclerosis

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Signalling mechanisms and oxidative stress in apoptosis

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A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes

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Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

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The use of tetrazolium salts to determine sites of damage to the mitochondrial electron transport chain in intact cells following in vitro photodynamic therapy with Photofrin II

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Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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Lipid peroxidation in rat brain cortical slices as measured by the thiobarbituric acid test

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12 December 2020

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

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Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

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Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury.

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Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis

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Oxygen free radicals and brain dysfunction

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A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

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Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: role of bcl-2.

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Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal by mitochondria isolated from rat kidney cortex.

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Mechanisms and genes of cellular suicide

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Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

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Aurintricarboxylic acid is an inhibitor of mu- and m-calpain

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Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

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12 December 2020

Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

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Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis.

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The impairment of mitochondrial membrane potential and mass in proliferating lymphocytes from vitamin E deficient animals is recovered by glutathione

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12 December 2020

Hydrogen peroxide mediates amyloid beta protein toxicity

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12 December 2020

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

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12 December 2020

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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12 December 2020

Role of cardiac glutathione transferase and of the glutathione S-conjugate export system in biotransformation of 4-hydroxynonenal in the heart

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12 December 2020

Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins

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12 December 2020

Glutathione metabolism.

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12 December 2020

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Effects of microtubule stabilization and destabilization on tau immunoreactivity in cultured hippocampal neurons

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Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

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Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons.

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12 December 2020

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12 December 2020

Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

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12 December 2020

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

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12 December 2020

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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12 December 2020

Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury

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12 December 2020

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction

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12 December 2020

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

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12 December 2020

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress?

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12 December 2020

Metabolism of 4-hydroxynonenal, a cytotoxic lipid peroxidation product, in Ehrlich mouse ascites cells at different proliferation stages

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12 December 2020

Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability

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12 December 2020

Role of oxidants in ischemic brain damage

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12 December 2020

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

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12 December 2020

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons

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12 December 2020

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12 December 2020

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12 December 2020

Expression of bcl-2 inhibits cellular radical generation

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12 December 2020

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12 December 2020

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis.

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12 December 2020

10.1523/JNEUROSCI.17-13-05089.1997

Identifiers

DOI

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3 November 2019

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3 November 2019

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