Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. (Q48708288)

PubMed publication ID

16267225

14 February 2018

http://europepmc.org/abstract/MED/16267225

title

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725803&resulttype=core&format=json

12 May 2020

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6

Thomas J Montine

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725803&resulttype=core&format=json

12 May 2020

author name string

Xibin Liang

1

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12 May 2020

Qian Wang

2

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12 May 2020

Tracey Hand

3

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12 May 2020

Liejun Wu

4

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12 May 2020

Richard M Breyer

5

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12 May 2020

Katrin Andreasson

7

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12 May 2020

language of work or name

English

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publication date

1 November 2005

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PubMed publication ID

16267225

14 February 2018

http://europepmc.org/abstract/MED/16267225

published in

Journal of Neuroscience

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12 May 2020

volume

25

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12 May 2020

issue

44

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12 May 2020

page(s)

10180-10187

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beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease

12 May 2020

cites work

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Elevated CSF prostaglandin E2 levels in patients with probable AD

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Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease.

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Inflammation and Alzheimer's disease

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

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Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

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Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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Oxidative stress increases expression and activity of BACE in NT2 neurons

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Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent

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Effect of antipyretics on polymorphonuclear leukocyte functions in children

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Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

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No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

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The LPS receptor (CD14) links innate immunity with Alzheimer's disease

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

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Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay

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Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

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Beta-secretase activity increases with aging in human, monkey, and mouse brain.

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12 December 2020

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

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12 December 2020

Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

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12 December 2020

Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP.

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12 December 2020

Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review

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12 December 2020

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

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12 December 2020

Deciphering the molecular basis of memory failure in Alzheimer's disease

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12 December 2020

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

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12 December 2020

Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo

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Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases.

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Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

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Post-translational processing of beta-secretase in Alzheimer's disease

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Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity

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Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

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Ozone reduces murine alveolar and peritoneal macrophage phagocytosis: the role of prostanoids

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Reversal of virus-induced alveolar macrophage bactericidal dysfunction by cyclooxygenase inhibition in vitro

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Characterization of prostanoid relaxant/inhibitory receptors (psi) using a highly selective agonist, TR4979.

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12 December 2020

Prostaglandin-mediated suppression of macrophage phagocytosis of Listeria monocytogenes

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12 December 2020

Nonsteroidal anti-inflammatory drugs correct the bactericidal defect of polymorphonuclear leukocytes in a guinea pig model of thermal injury

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12 December 2020

Factors that influence the suppression of pulmonary antibacterial defenses in mice exposed to ozone

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12 December 2020

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs.

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12 December 2020

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

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12 December 2020

Risk of Alzheimer's disease and duration of NSAID use.

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12 December 2020

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

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12 December 2020

Role of arachidonic acid metabolites in the action of a beta adrenergic agonist on human monocyte phagocytosis

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12 December 2020

10.1523/JNEUROSCI.3591-05.2005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725803&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725803&resulttype=core&format=json

12 May 2020

PubMed publication ID

16267225

1 reference