Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB. (Q48880415)

16 February 2018

title

Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB. (English)

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16 February 2018

author

Hiroshi Kunugi

4

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16 February 2018

author name string

Emi Kumamaru

1

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16 February 2018

Tadahiro Numakawa

2

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Naoki Adachi

3

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language of work or name

English

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publication date

19 September 2011

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16 February 2018

published in

FEBS Letters

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16 February 2018

volume

585

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issue

20

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page(s)

3224-3228

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16 February 2018

Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression

cites work

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Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty

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The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects

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Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons

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Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter

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Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators

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Linking Molecules to Mood: New Insight Into the Biology of Depression

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Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation

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A new mechanism for the regulation of Gab1 recruitment to the plasma membrane.

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The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

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Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

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Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.

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Identifiers

DOI

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16 February 2018

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16 February 2018