Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain. (Q48881068)

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English	Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.	scientific article

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Europe PubMed Central

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16 February 2018

http://europepmc.org/abstract/MED/21945132

Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain (English)

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13 May 2020

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Xiaoping Du

1

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13 May 2020

Andrea J Elberger

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13 May 2020

Douglas B Matthews

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13 May 2020

Kristin M Hamre

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13 May 2020

publication date

14 September 2011

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16 February 2018

http://europepmc.org/abstract/MED/21945132

Neurotoxicology and Teratology

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13 May 2020

34

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13 May 2020

1

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13 May 2020

177-186

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13 May 2020

Chronic ethanol exposure and withdrawal influence NMDA receptor subunit and splice variant mRNA expression in the rat cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Identification and Confirmation of Quantitative Trait Loci Regulating Alcohol Consumption in Congenic Strains of Mice

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Effects of chronic alcohol consumption on the expression of different NR1 splice variants in the brain of AA and ANA lines of rats

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure.

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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In search of a new pharmacological treatment for drug and alcohol addiction: N-methyl-D-aspartate (NMDA) antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Ionotropic glutamate receptor subunit expression in the rat hippocampus: lack of an effect of a long-term ethanol exposure paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation

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https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Identity and neuroanatomical localization of messenger RNAs that change expression in the neural tube of mouse embryos within 1 h after ethanol exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Corpus callosum and visual cortex of mice with deletion of the NMDA-NR1 receptor: I. Accelerated development of callosal projection neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corpus callosum and visual cortex of mice with deletion of the NMDA-NR1 receptor. II. Attenuation of prenatal alcohol exposure effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Ethanol suppression of ventral tegmental area GABA neuron electrical transmission involves N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Integrated genomic and proteomic analyses of gene expression in Mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Signaling cascades regulating NMDA receptor sensitivity to ethanol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Detection of large-scale variation in the human genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Comparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (+-)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine (ADCI) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

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Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Chronic intermittent ethanol exposure enhances NMDA-receptor-mediated synaptic responses and NMDA receptor expression in hippocampal CA1 region

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Genetic inactivation of the NMDA receptor NR2A subunit has anxiolytic- and antidepressant-like effects in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Where do you think you are going? The NMDA-D1 receptor trap

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NR2C by NR2B subunit exchange in juvenile mice affects emotionality and 5-HT in the frontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant synaptic activation of N-methyl-D-aspartate receptors underlies ethanol withdrawal hyperexcitability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential gene expression in the hippocampus of the Df1/+ mice: a model for 22q11.2 deletion syndrome and schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic intermittent ethanol treatment selectively alters N-methyl-D-aspartate receptor subunit surface expression in cultured cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the stria terminalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Paradoxical facilitatory effect of low-dose alcohol consumption on memory mediated by NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-dopamine-GABA interactions in the aging basal ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and characterization of the rat NMDA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

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Genetic mapping of vocalization to a series of increasing acute footshocks using B6.A consomic and B6.D2 congenic mouse strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol related changes in regulation of NMDA receptor functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CGS 19755: a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant, anxiolytic and anti-ischemic properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed correlation of mRNA and protein expression in rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the non-competitive NMDA receptor antagonist memantine on the volitional consumption of ethanol by alcohol-preferring rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-methyl-d-aspartic acid receptors are altered by stress and alcohol in Wistar-Kyoto rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum play a crucial role in alcohol consumption and relapse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An NMDA receptor antagonist reduces ethanol preference in untrained but not trained rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of NMDA Receptor Subunit-Specific Antibodies: Distribution of NR2A and NR2B Receptor Subunits in Rat Brain and Ontogenic Profile in the Cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the NMDA receptor in ethanol withdrawal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of acute alcohol withdrawal on sensitivity to pro- and anticonvulsant treatments in WSP mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of NMDA-R1 antisense oligodeoxynucleotide administration: behavioral and radioligand binding studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic ethanol consumption: from neuroadaptation to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption

1 reference

https://pubmed.ncbi.nlm.nih.gov/21945132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NTT.2011.09.001

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410725&resulttype=core&format=json

13 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410725&resulttype=core&format=json

13 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6410725&resulttype=core&format=json

13 May 2020

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