GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. (Q48892550)

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scientific article published in October 1996

Language	Label	Description	Also known as
English	GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element.	scientific article published in October 1996

Statements

scholarly article

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. (English)

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

Michael C. Ostrowski

4

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

author name string

Bradford AP

1

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Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

Conrad KE

2

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

Tran PH

3

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

Gutierrez-Hartmann A

5

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

language of work or name

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publication date

1 October 1996

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Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

Journal of Biological Chemistry

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Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

271

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16 February 2018

http://europepmc.org/abstract/MED/8798730

24639-24648

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Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

40

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Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

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Nuclear targets for transcription regulation by oncogenes

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Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

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The many roads that lead to Ras.

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Ras-effector interactions, the problem of specificity.

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Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

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Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells

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Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells

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Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression

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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

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The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

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Net, a new ets transcription factor that is activated by Ras

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ras oncogene activation of a VL30 transcriptional element is linked to transformation

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Transcriptional activation of a conserved sequence element by ras requires a nuclear factor distinct from c-fos or c-jun

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Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes

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Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

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c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.

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Transformation suppressor activity of a Jun transcription factor lacking its activation domain

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Transfected human beta-polymerase promoter contains a ras-responsive element

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Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

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Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase

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Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter

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The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

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21 January 2018

Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression: mapping of the essential c-Ets-1 domain

1 reference

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21 January 2018

Identification of the functional components of the Ras signaling pathway regulating pituitary cell-specific gene expression

1 reference

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21 January 2018

Analysis of rat prolactin promoter sequences that mediate pituitary-specific and 3',5'-cyclic adenosine monophosphate-regulated gene expression in vivo

1 reference

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Function of the Homeodomain Protein GHF1 in Pituitary Cell Proliferation

1 reference

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A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1 reference

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21 January 2018

A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways

1 reference

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21 January 2018

Selective transcription and DNase I protection of the rat prolactin gene by GH3 pituitary cell-free extracts

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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Thyrotropin-releasing hormone and epidermal growth factor induce human prolactin expression via identical multiple cis elements

1 reference

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21 January 2018

Clustered point mutation analysis of the rat prolactin promoter

1 reference

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Reconstitution of protein kinase A regulation of the rat prolactin promoter in HeLa nonpituitary cells: identification of both GHF-1/Pit-1-dependent and -independent mechanisms

1 reference

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21 January 2018

Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters

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Triggering signaling cascades by receptor tyrosine kinases

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Epidermal growth factor and Ras regulate gene expression in GH4 pituitary cells by separate, antagonistic signal transduction pathways

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A consensus insulin response element is activated by an Ets-related transcription factor.

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21 January 2018

The Ets family of transcription factors

1 reference

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Structure of serum response factor core bound to DNA

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ets-1 in astrocytes: expression and transmitter-evoked phosphorylation

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The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation

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Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

1 reference

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Binding of a 100-kDa ubiquitous factor to the human prolactin promoter is required for its basal and hormone-regulated activity

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GABP mediates insulin-increased prolactin gene transcription

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Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins

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A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.

1 reference

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Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene

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Integration of MAP kinase signal transduction pathways at the serum response element

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Identifiers

10.1074/JBC.271.40.24639

1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

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https://api.fatcat.wiki/v0/release/unlyvdy4ivgo3o2bp4e6tu77v4

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1 reference

Europe PubMed Central

16 February 2018

http://europepmc.org/abstract/MED/8798730

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