Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. (Q48972434)

17 February 2018

title

Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. (English)

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17 February 2018

infection of the central nervous system

main subject

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toll-like receptor

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pneumococcal infection

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1

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Hermann Wagner

5

object named as

Hermann Wagner

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Carsten J Kirschning

7

object named as

Carsten J Kirschning

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Barbara Angele

3

object named as

Barbara Angele

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author name string

Bianca Obermaier

2

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Hans-Walter Pfister

4

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Uwe Koedel

6

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language of work or name

English

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publication date

1 October 2008

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Journal of Infectious Diseases

published in

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volume

198

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issue

7

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page(s)

1028-1036

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Dexamethasone in adults with bacterial meningitis

cites work

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Pneumococcal meningitis in adults: Spectrum of complications and prognostic factors in a series of 87 cases

21 January 2018

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Oxidative stress in pneumococcal meningitis: a future target for adjunctive therapy?

21 January 2018

1 reference

Decreased virulence of a pneumolysin-deficient strain of Streptococcus pneumoniae in murine meningitis

21 January 2018

1 reference

The role of pneumolysin in pneumococcal pneumonia and meningitis

21 January 2018

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Streptococcus pneumoniae deficient in pneumolysin or autolysin has reduced virulence in meningitis.

21 January 2018

1 reference

MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS.

21 January 2018

1 reference

MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis.

21 January 2018

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Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.

21 January 2018

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Regulation of Streptococcus pneumoniae distribution by Toll-like receptor 2 in vivo.

21 January 2018

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Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae.

21 January 2018

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Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns

21 January 2018

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Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

21 January 2018

1 reference

A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2.

21 January 2018

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TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae

21 January 2018

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Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection

21 January 2018

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Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase

21 January 2018

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Protein expression pattern in experimental pneumococcal meningitis

21 January 2018

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Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice

21 January 2018

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Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses

21 January 2018

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Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

21 January 2018

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Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci

21 January 2018

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Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis.

21 January 2018

1 reference

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

21 January 2018

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Cultured astrocytes express toll-like receptors for bacterial products.

21 January 2018

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Expression and distribution of Toll-like receptors in the brain during murine neurocysticercosis

21 January 2018

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Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists.

21 January 2018

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Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages

21 January 2018

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Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells

21 January 2018

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Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1086/591626

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17 February 2018

PubMed ID

18700834

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17 February 2018