The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. (Q49138161)

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scientific article published in June 2011

The Second-Generation Active A Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

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English	The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.	scientific article published in June 2011	The Second-Generation Active A Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

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5 February 2020

The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects (English)

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Laura H Jacobson

6

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Martin F. Bachmann

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Martin F Bachmann

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Christoph Wiessner

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Karl-Heinz Wiederhold

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Alain C Tissot

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Peter Frey

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Simone Danner

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5 February 2020

Gary T Jennings

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Rainer Lüönd

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Rainer Ortmann

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Julia Reichwald

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5 February 2020

Mauro Zurini

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5 February 2020

Anis Mir

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5 February 2020

Matthias Staufenbiel

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1 June 2011

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Journal of Neuroscience

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9323-9331

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5 February 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiplexed particle-based flow cytometric assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral hemorrhage after passive anti-Abeta immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic approaches to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: strategies for disease modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origin, structure and motifs of naturally processed MHC class II ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemistry of peptides associated with MHC class I and class II molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

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The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of antigen organization on B cell responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptides naturally presented by MHC class I molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron loss in APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21697382

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0293-11.2011

1 reference

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5 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21697382%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21697382%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

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