Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer. (Q50056278)

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scientific article published on 6 February 2018

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English	Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.	scientific article published on 6 February 2018

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16 March 2020

Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer (English)

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16 March 2020

Kathy K. Griendling

10

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16 March 2020

Samantha M Yeligar

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16 March 2020

Alejandra San Martín

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16 March 2020

Victor Darley-Usmar

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Victor Darley-Usmar

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16 March 2020

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Felipe Paredes

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16 March 2020

Kely Sheldon

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16 March 2020

Bernard Lassègue

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16 March 2020

Holly C Williams

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16 March 2020

Elizabeth A Faidley

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16 March 2020

Gloria A Benavides

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16 March 2020

Gloria Torres

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16 March 2020

Fernanda Sanhueza-Olivares

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16 March 2020

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6 February 2018

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16 March 2020

Proceedings of the National Academy of Sciences of the United States of America

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16 March 2020

115

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16 March 2020

8

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16 March 2020

1789-1794

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16 March 2020

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

6 February 2018

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Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes.

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Lipoamide dehydrogenase deficiency with primary lactic acidosis: favorable response to treatment with oral lipoic acid

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Identifiers

10.1073/PNAS.1720693115

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29434038%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PMC publication ID

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16 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29434038%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

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