Essential role of MD-2 in LPS responsiveness and TLR4 distribution. (Q50109313)

25 February 2018

title

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. (English)

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25 February 2018

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Yoichiro Iwakura

5

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author name string

Yoshinori Nagai

1

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Sachiko Akashi

2

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Masakazu Nagafuku

3

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Masato Ogata

4

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Shizuo Akira

6

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Toshio Kitamura

7

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Atsushi Kosugi

8

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Masao Kimoto

9

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Kensuke Miyake

10

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language of work or name

English

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publication date

10 June 2002

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25 February 2018

published in

Nature Immunology

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volume

3

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page(s)

667-672

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issue

7

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Innate immune recognition

cites work

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7 January 2021

Toll-like receptors in the induction of the innate immune response

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The instructive role of innate immunity in the acquired immune response

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CD14 is a pattern recognition receptor

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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A family of human receptors structurally related to Drosophila Toll

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

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Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells

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The molecular mechanism of B cell activation by toll-like receptor protein RP-105

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Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide

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7 January 2021

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

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7 January 2021

MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor

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7 January 2021

N-linked glycosylations at Asn(26) and Asn(114) of human MD-2 are required for toll-like receptor 4-mediated activation of NF-kappaB by lipopolysaccharide

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7 January 2021

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

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7 January 2021

Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4

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7 January 2021

Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.

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7 January 2021

Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages.

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

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Transport of bacterial lipopolysaccharide to the golgi apparatus

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ER-Tracker dye and BODIPY-brefeldin A differentiate the endoplasmic reticulum and golgi bodies from the tubular-vacuole system in living hyphae of Pisolithus tinctorius.

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Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

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Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

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Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

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Cutting edge: Gln22 of mouse MD-2 is essential for species-specific lipopolysaccharide mimetic action of taxol

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Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition

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Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

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Human Toll-like receptor 4 recognizes host-specific LPS modifications.

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A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene.

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

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The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

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Plat-E: an efficient and stable system for transient packaging of retroviruses

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Identifiers

DOI

10.1038/NI809

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25 February 2018

PubMed ID

12055629

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25 February 2018