COP9 signalosome subunit 3 (Q5013423)

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mammalian protein found in Homo sapiens

• COP9 signalosome complex subunit 3
• JAB1-containing signalosome subunit 3
• COPS3
• COP9 constitutive photomorphogenic homolog subunit 3
• COP9 complex subunit 3
• signalosome subunit 3

edit

Language	Label	Description	Also known as
English	COP9 signalosome subunit 3	mammalian protein found in Homo sapiens	COP9 signalosome complex subunit 3 JAB1-containing signalosome subunit 3 COPS3 COP9 constitutive photomorphogenic homolog subunit 3 COP9 complex subunit 3 signalosome subunit 3

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UNS2

part of

Winged helix DNA-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UNS2

Winged helix-like DNA-binding domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UNS2

COP9 signalosome complex subunit 3

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UNS2

Proteasome component (PCI) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UNS2

encoded by

COPS3

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UNS2

molecular function

protein binding

determination method

IPI

12 references

retrieved

8 April 2019

stated in

Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

Crystal structure of the human COP9 signalosome

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

Defining the human deubiquitinating enzyme interaction landscape

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

Dynamic regulation of the COP9 signalosome in response to DNA damage

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

retrieved

8 April 2019

stated in

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IPI

cell component

COP9 signalosome

determination method

IDA

IEA

4 references

retrieved

27 February 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNS2&geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

27 February 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNS2&geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

27 February 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNS2&geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

27 February 2018

stated in

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UNS2&geneProductId=UniProtKB:Q9UNS2

determination method

IDA

nucleus

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IDA

nucleoplasm

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IDA

cytoplasm

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IEA

cytosol

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IDA

COP9 signalosome

determination method

IBA

IDA

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IEA

retrieved

8 April 2019

stated in

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IBA

biological process

transcription-coupled nucleotide-excision repair

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

in utero embryonic development

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IEA

ubiquitin-dependent protein catabolic process

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IBA

nucleotide-excision repair, DNA damage recognition

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

signal transduction

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

response to light stimulus

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

protein deneddylation

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality

GOA

curator

UniProt

UniProt protein ID

Q9UNS2

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

IDA

post-translational protein modification

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UNS2

determination method

TAS

Gene Atlas image

PBB GE COPS3 202078 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/Q9UNS2

1 reference

stated in

Identifiers.org

has part(s)

Proteasome component (PCI) domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9UNS2

Identifiers

RefSeq protein ID

NP_001186054

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

NP_001303283

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

NP_001303284

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

NP_001303285

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

NP_001303286

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

NP_001303287

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

NP_003644

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

XP_005256894

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

XP_005256897

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

XP_005256899

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

XP_016880735

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

8533

UniProt protein ID

Q9UNS2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9UNS2

Ensembl protein ID

ENSP00000268717

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000268717

ENSP00000437606

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000437606

ENSP00000409028

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000409028

ENSP00000413298

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000413298

ENSP00000463098

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463098

ENSP00000463195

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463195

ENSP00000463340

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463340

ENSP00000463477

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000463477

ENSP00000464369

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000464369

ENSP00000464572

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000464572

ENSP00000465156

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000465156

ENSP00000466153

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000466153

ENSP00000468536

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000468536

PDB structure ID

4D10

1 reference

stated in

UniProt

UniProt protein ID

Q9UNS2

retrieved

9 August 2016

language of work or name

English

4D18

1 reference

stated in

UniProt

UniProt protein ID

Q9UNS2

retrieved

9 August 2016

language of work or name

English

4WSN

1 reference

stated in

UniProt

UniProt protein ID

Q9UNS2

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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