cytochrome P450 family 2 subfamily C member 9 (Q5014962)

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mammalian protein found in Homo sapiens

• flavoprotein-linked monooxygenase
• 1.14.99.38
• S-mephenytoin 4-hydroxylase
• cytochrome P450, family 2, subfamily C, polypeptide 9
• (R)-limonene 6-monooxygenase
• microsomal monooxygenase
• 1.14.13.80
• xenobiotic monooxygenase
• cytochrome P-450MP
• CYPIIC9
• cytochrome P450 PB-1
• cytochrome P450 2C9
• (S)-limonene 6-monooxygenase
• 1.14.13.48
• cytochrome P-450 S-mephenytoin 4-hydroxylase
• Cytochrome P450 MP-4
• CYP2C9
• (S)-limonene 7-monooxygenase
• 1.14.13.49
• Cholesterol 25-hydroxylase
• Cytochrome P450 MP-8

edit

Language	Label	Description	Also known as
English	cytochrome P450 family 2 subfamily C member 9	mammalian protein found in Homo sapiens	flavoprotein-linked monooxygenase 1.14.99.38 S-mephenytoin 4-hydroxylase cytochrome P450, family 2, subfamily C, polypeptide 9 (R)-limonene 6-monooxygenase microsomal monooxygenase 1.14.13.80 xenobiotic monooxygenase cytochrome P-450MP CYPIIC9 cytochrome P450 PB-1 cytochrome P450 2C9 (S)-limonene 6-monooxygenase 1.14.13.48 cytochrome P-450 S-mephenytoin 4-hydroxylase Cytochrome P450 MP-4 CYP2C9 (S)-limonene 7-monooxygenase 1.14.13.49 Cholesterol 25-hydroxylase Cytochrome P450 MP-8

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11712

part of

cytochrome P450 superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11712

cytochrome P450, E-class, group I

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11712

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11712

encoded by

CYP2C9

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11712

molecular function

iron ion binding

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

arachidonic acid epoxygenase activity

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

metal ion binding

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

steroid hydroxylase activity

determination method or standard

IMP

1 reference

retrieved

24 April 2018

stated in

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

IMP

caffeine oxidase activity

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

heme binding

determination method or standard

IEA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

IEA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

oxidoreductase activity

determination method or standard

IDA

IEA

3 references

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

retrieved

9 May 2019

stated in

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

retrieved

9 May 2019

stated in

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

monooxygenase activity

determination method or standard

IEA

IDA

NAS

TAS

4 references

retrieved

10 September 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

10 September 2018

stated in

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

NAS

retrieved

10 September 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

IEA

retrieved

10 September 2018

stated in

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

IDA

steroid hydroxylase activity

determination method or standard

IBA

IMP

2 references

retrieved

9 May 2019

stated in

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IMP

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

heme binding

determination method or standard

IBA

IEA

2 references

retrieved

9 May 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

monooxygenase activity

determination method or standard

IDA

IEA

NAS

3 references

retrieved

9 May 2019

stated in

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

NAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

retrieved

9 May 2019

stated in

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

cell component

organelle membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

endoplasmic reticulum membrane

determination method or standard

IEA

TAS

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

membrane

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

intracellular membrane-bounded organelle

determination method or standard

IDA

IEA

TAS

4 references

retrieved

24 April 2018

stated in

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

24 April 2018

stated in

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

24 April 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

IEA

retrieved

24 April 2018

stated in

Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

IDA

endoplasmic reticulum

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

cytoplasm

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

intracellular membrane-bounded organelle

determination method or standard

IBA

IDA

IEA

TAS

5 references

retrieved

9 May 2019

stated in

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

9 May 2019

stated in

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

retrieved

9 May 2019

stated in

Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

biological process

steroid metabolic process

determination method or standard

IEA

IMP

2 references

retrieved

9 May 2019

stated in

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IMP

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

lipid metabolism

determination method or standard

IEA

1 reference

retrieved

9 May 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IEA

cellular amide metabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

epoxygenase P450 pathway

determination method or standard

IBA

TAS

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

monocarboxylic acid metabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

oxidative demethylation

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

omega-hydroxylase P450 pathway

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

monoterpenoid metabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

xenobiotic metabolic process

determination method or standard

TAS

1 reference

retrieved

24 April 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method or standard

TAS

urea metabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

long-chain fatty acid biosynthetic process

determination method or standard

TAS

1 reference

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

organic acid metabolic process

determination method or standard

IBA

1 reference

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

xenobiotic metabolic process

determination method or standard

IBA

TAS

2 references

retrieved

9 May 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

TAS

retrieved

9 May 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IBA

estrogen metabolic process

determination method or standard

IDA

1 reference

retrieved

9 May 2019

stated in

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms

GOA

curator

UniProt

UniProt protein ID

P11712

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method or standard

IDA

physically interacts with

liver kidney microsomal type 2 antibody

subject has role

antigen

0 references

EC enzyme number

1.14.14.51

1 reference

stated in

ENZYME

retrieved

9 September 2019

Gene Atlas image

PBB GE CYP2C9 214421 x at fs.png
732 × 530; 8 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P11712

1 reference

stated in

Identifiers.org

has part(s)

cytochrome P450, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11712

Commons category

CYP2C9

0 references

Identifiers

MeSH descriptor ID

D065729

subject named as

Cytochrome P-450 CYP2C9

0 references

MeSH tree code

D08.244.453.491.500.500

0 references

D08.811.682.690.708.170.450.500.500

0 references

D12.776.422.220.453.491.500.500

0 references

RefSeq protein ID

NP_000762

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1559

UniProt protein ID

P11712

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11712

Ensembl protein ID

ENSP00000260682

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000260682

ENSP00000496202

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496202

ENSP00000495649

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000495649

Freebase ID

/m/0cmxzl

0 references

Microsoft Academic ID

3946865

0 references

OpenAlex ID

C3946865

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1OG2

1 reference

stated in

UniProt

UniProt protein ID

P11712

retrieved

9 August 2016

language of work or name

English

1OG5

1 reference

stated in

UniProt

UniProt protein ID

P11712

retrieved

9 August 2016

language of work or name

English

1R9O

1 reference

stated in

UniProt

UniProt protein ID

P11712

retrieved

9 August 2016

language of work or name

English

4NZ2

1 reference

stated in

UniProt

UniProt protein ID

P11712

retrieved

9 August 2016

language of work or name

English

UMLS CUI

C1828473

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

25 May 2023

 

Sitelinks

Wikipedia(9 entries)

edit

• cywiki CYP2C9
• dewiki Cytochrom P450 2C9
• enwiki CYP2C9
• eswiki CYP2C9
• fawiki CYP2C9
• lawiki CYP2C9
• thwiki CYP2C9
• ukwiki CYP2C9
• zhwiki CYP2C9

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(1 entry)

edit

• commonswiki Category:CYP2C9

Retrieved from "https://www.wikidata.org/w/index.php?title=Q5014962&oldid=2022906743"