cytochrome P450 family 2 subfamily C member 9 (Q5014962)

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mammalian protein found in Homo sapiens

flavoprotein-linked monooxygenase
1.14.99.38
S-mephenytoin 4-hydroxylase
cytochrome P450, family 2, subfamily C, polypeptide 9
(R)-limonene 6-monooxygenase
microsomal monooxygenase
1.14.13.80
xenobiotic monooxygenase
cytochrome P-450MP
CYPIIC9
cytochrome P450 PB-1
cytochrome P450 2C9
(S)-limonene 6-monooxygenase
1.14.13.48
cytochrome P-450 S-mephenytoin 4-hydroxylase
Cytochrome P450 MP-4
CYP2C9
(S)-limonene 7-monooxygenase
1.14.13.49
Cholesterol 25-hydroxylase
Cytochrome P450 MP-8

Language	Label	Description	Also known as
English	cytochrome P450 family 2 subfamily C member 9	mammalian protein found in Homo sapiens	flavoprotein-linked monooxygenase 1.14.99.38 S-mephenytoin 4-hydroxylase cytochrome P450, family 2, subfamily C, polypeptide 9 (R)-limonene 6-monooxygenase microsomal monooxygenase 1.14.13.80 xenobiotic monooxygenase cytochrome P-450MP CYPIIC9 cytochrome P450 PB-1 cytochrome P450 2C9 (S)-limonene 6-monooxygenase 1.14.13.48 cytochrome P-450 S-mephenytoin 4-hydroxylase Cytochrome P450 MP-4 CYP2C9 (S)-limonene 7-monooxygenase 1.14.13.49 Cholesterol 25-hydroxylase Cytochrome P450 MP-8

Statements

1 reference

13 November 2019

UniProt protein ID

cytochrome P450 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11712

cytochrome P450, E-class, group I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11712

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

iron ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

arachidonic acid epoxygenase activity

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

steroid hydroxylase activity

determination method

1 reference

24 April 2018

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

caffeine oxidase activity

determination method

1 reference

9 May 2019

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

oxidoreductase activity

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

monooxygenase activity

determination method

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

10 September 2018

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

10 September 2018

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

monooxygenase activity

determination method

3 references

9 May 2019

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

organelle membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

intracellular membrane-bounded organelle

determination method

4 references

24 April 2018

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

24 April 2018

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

24 April 2018

Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

intracellular membrane-bounded organelle

determination method

5 references

9 May 2019

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

biological process

lipid metabolism

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

cellular amide metabolic process

determination method

1 reference

9 May 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

monocarboxylic acid metabolic process

determination method

1 reference

9 May 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

oxidative demethylation

determination method

1 reference

9 May 2019

The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

omega-hydroxylase P450 pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

monoterpenoid metabolic process

determination method

1 reference

9 May 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

xenobiotic metabolic process

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11712&geneProductId=UniProtKB:P11712

determination method

urea metabolic process

determination method

1 reference

9 May 2019

Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

long-chain fatty acid biosynthetic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

organic acid metabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

estrogen metabolic process

determination method

1 reference

9 May 2019

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11712

determination method

physically interacts with

liver kidney microsomal type 2 antibody

subject has role

0 references

EC enzyme number

1.14.14.51

1 reference

9 September 2019

Gene Atlas image

PBB GE CYP2C9 214421 x at fs.png
732 × 530; 8 KB

0 references

http://purl.uniprot.org/uniprot/P11712

1 reference

Identifiers.org

cytochrome P450, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P11712

Commons category

CYP2C9

0 references

Identifiers

MeSH descriptor ID

subject named as

Cytochrome P-450 CYP2C9

0 references

D08.244.453.491.500.500

0 references

D08.811.682.690.708.170.450.500.500

0 references

D12.776.422.220.453.491.500.500

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000260682

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000260682

ENSP00000496202

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496202

ENSP00000495649

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495649

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(9 entries)

cywiki CYP2C9
dewiki Cytochrom P450 2C9
enwiki CYP2C9
eswiki CYP2C9
fawiki CYP2C9
lawiki CYP2C9
thwiki CYP2C9
ukwiki CYP2C9
zhwiki CYP2C9

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:CYP2C9

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