Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. (Q50336184)

5 March 2018

title

Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. (English)

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5 March 2018

CAAX-box protein maturation

main subject

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Gene Ontology release 2020-05-02

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3

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5 March 2018

Miguel C. Seabra

5

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author name string

Ka Fai Leung

1

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5 March 2018

Rudi Baron

2

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Anthony I Magee

4

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language of work or name

English

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publication date

18 November 2006

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5 March 2018

Journal of Biological Chemistry

published in

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volume

282

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issue

2

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5 March 2018

page(s)

1487-1497

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Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I

cites work

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cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

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Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

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Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

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Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

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Carboxyl methylation of Ras regulates membrane targeting and effector engagement

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Isoprenylation of Rab proteins possessing a C-terminal CaaX motif

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Membrane targeting of Rab GTPases is influenced by the prenylation motif

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21 January 2018

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The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities

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Nalpha -terminal acetylation of eukaryotic proteins

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Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts

21 January 2018

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Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

21 January 2018

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21 January 2018

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Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

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21 January 2018

Identifiers

DOI

10.1074/JBC.M605557200

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5 March 2018

PubMed ID

17114793

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5 March 2018