Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells (Q50539714)

15 March 2018

title

Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells (English)

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6

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Martin Irmler

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Antonio Giordano

9

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Nicola Alessio

object named as

Nicola Alessio

1

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Marilena Cipollaro

object named as

Marilena Cipollaro

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Umberto Galderisi

object named as

Umberto Galderisi

10

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author name string

Wolfgang Bohn

2

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Verena Rauchberger

3

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Flavio Rizzolio

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Johannes Beckers

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publication date

31 January 2013

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Cellular and Molecular Life Sciences

published in

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volume

70

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issue

9

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15 March 2018

page(s)

1637-1651

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Cellular senescence in cancer and aging

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

The retinoblastoma gene is involved in multiple aspects of stem cell biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Cell cycle regulation and neural differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Cell type-specific effects of Rb deletion in the murine retina.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Bone marrow stromal stem cells: nature, biology, and potential applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

The stromal cells' guide to the stem cell universe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Bone marrow-derived cells: the influence of aging and cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Aging of mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Quantitative assay of senescence-associated beta-galactosidase activity in mammalian cell extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Human diploid fibroblast cells in senescence; cycling through polyploidy to mitotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

DNA repair, genome stability, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

DNA damage-induced cell death by apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

UV damage, DNA repair and skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Mechanism of oxidative DNA damage repair and relevance to human pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Cellular senescence: when bad things happen to good cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

RB and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Changes in retinoblastoma cell adhesion associated with optic nerve invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Redox regulation of stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Senescence-messaging secretome: SMS-ing cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Epstein-barr virus-induced expression of a novel human vault RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Nucleolus, ribosomes, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Elevated transcription of the p53 gene in early S-phase leads to a rapid DNA-damage response during S-phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Cooperation between p53 and p130(Rb2) in induction of cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

How to become immortal: let MEFs count the ways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Regulation of cellular senescence by Rb2/p130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Tumour suppressor retinoblastoma protein Rb: a transcriptional regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1224-X

Single-cell analysis of p16(INK4a) and p21(WAF1) expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts.

21 January 2018

1 reference

12 December 2020

Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage

1 reference

12 December 2020

Differentiation and apoptosis of neuroblastoma cells: role of N-myc gene product

1 reference

12 December 2020

DNA topoisomerases in cancer chemotherapy: using enzymes to generate selective DNA damage

1 reference

12 December 2020

Colony forming unit assays for MSCs

1 reference

12 December 2020

Tumour suppression by p53: the importance of apoptosis and cellular senescence

1 reference

12 December 2020

Mesenchymal stem cells: isolation, in vitro expansion and characterization

1 reference

12 December 2020

Culture medium study of human mesenchymal stem cells for practical use of tissue engineering and regenerative medicine

1 reference

12 December 2020

p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107.

1 reference

12 December 2020

Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

1 reference

12 December 2020

The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain

1 reference

12 December 2020

Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother.

1 reference

12 December 2020

RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells

1 reference

12 December 2020

Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation.

1 reference

12 December 2020

Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model.

1 reference

12 December 2020

10.1007/S00018-012-1224-X

Identifiers

DOI

1 reference

15 March 2018

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15 March 2018