Transferrin therapy ameliorates disease in beta-thalassemic mice. (Q50586962)

16 March 2018

title

Transferrin therapy ameliorates disease in beta-thalassemic mice. (English)

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16 March 2018

author name string

Huihui Li

1

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16 March 2018

Anne C Rybicki

2

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Sandra M Suzuka

3

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Leni von Bonsdorff

4

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William Breuer

5

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Charles B Hall

6

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Z Ioav Cabantchik

7

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Eric E Bouhassira

8

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Mary E Fabry

9

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16 March 2018

Yelena Z Ginzburg

10

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language of work or name

English

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publication date

24 January 2010

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16 March 2018

published in

Nature Medicine

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16 March 2018

volume

16

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issue

2

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16 March 2018

page(s)

177-182

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16 March 2018

https://scigraph.springernature.com/pub.10.1038/nm.2073

exact match

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cites work

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

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Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation

21 January 2018

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Blood ferrokinetics in normal man

21 January 2018

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Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia

21 January 2018

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Competitive advantage of diferric transferrin in delivering iron to reticulocytes

21 January 2018

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12 December 2020

Occupancy of the iron binding sites of human transferrin

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12 December 2020

Hepcidin in iron overload disorders

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12 December 2020

Iron absorption and loading in beta-thalassaemia intermedia

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12 December 2020

Labile plasma iron in iron overload: redox activity and susceptibility to chelation

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The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major.

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The effect of erythroid hyperplasia on iron balance

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12 December 2020

Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator

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12 December 2020

Exogenous iron increases hemoglobin in beta-thalassemic mice

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12 December 2020

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

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12 December 2020

Pathophysiology of thalassaemia

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12 December 2020

Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation

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12 December 2020

Development of a pharmaceutical apotransferrin product for iron binding therapy

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12 December 2020

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

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12 December 2020

Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia

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12 December 2020

The role of membrane skeletal-associated alpha-globin in the pathophysiology of beta-thalassemia

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12 December 2020

A mouse model for β-thalassemia

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12 December 2020

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

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12 December 2020

Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo

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12 December 2020

A new mathematical model for relative quantification in real-time RT-PCR

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12 December 2020

Differential regulatory and compensatory responses in hematopoiesis/erythropoiesis in alpha- and beta-globin hemizygous mice

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Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification.

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12 December 2020

Effect of repeated apotransferrin administrations on serum iron parameters in patients undergoing myeloablative conditioning and allogeneic stem cell transplantation.

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12 December 2020

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

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12 December 2020

Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia.

1 reference

12 December 2020

Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure

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12 December 2020

The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major.

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12 December 2020

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment

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12 December 2020

The physiology of transferrin and transferrin receptors

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12 December 2020

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

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12 December 2020

Tissue iron deposition in untransfused beta-thalassemic mice

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12 December 2020

Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias

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12 December 2020

Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

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12 December 2020

Regulators of iron balance in humans

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12 December 2020

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

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12 December 2020

Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice

1 reference

12 December 2020

Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts

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12 December 2020

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

1 reference

12 December 2020

Decreased hepcidin mRNA expression in thalassemic mice

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12 December 2020

Identifiers

DOI

10.1038/NM.2073

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16 March 2018

Dimensions Publication ID

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16 March 2018