Final report on the united states phase i clinical trial of the hypoxic cell radiosensitizer, misonidazole (RO-07-0582; NSC #261037) (Q50599479)

16 March 2018

title

Final report on the united states phase i clinical trial of the hypoxic cell radiosensitizer, misonidazole (RO-07-0582; NSC #261037) (English)

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

12 September 2023

main subject

phase I clinical trial

0 references

hypoxia

0 references

United States of America

0 references

1 reference

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

12 September 2023

author name string

VanRaalte G

5

1 reference

16 March 2018

T. L. Phillips

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6269723

12 September 2023

T. H. Wasserman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6269723

12 September 2023

R. J. Johnson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6269723

12 September 2023

V. A. Levin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6269723

12 September 2023

G. VanRaalte

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A6269723

12 September 2023

language of work or name

English

0 references

publication date

1 October 1981

1 reference

16 March 2018

15 October 1981

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=6269723

full work available at URL

12 September 2023

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

https://onlinelibrary.wiley.com/doi/full/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

12 September 2023

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

12 September 2023

1 reference

16 March 2018

volume

48

1 reference

16 March 2018

issue

8

1 reference

16 March 2018

page(s)

1697-1704

1 reference

16 March 2018

Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results

cites work

1 reference

https://api.crossref.org/works/10.1002%2F1097-0142%2819811015%2948%3A8%3C1697%3A%3AAID-CNCR2820480802%3E3.0.CO%3B2-W

Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0142%2819811015%2948%3A8%3C1697%3A%3AAID-CNCR2820480802%3E3.0.CO%3B2-W

Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-0142%2819811015%2948%3A8%3C1697%3A%3AAID-CNCR2820480802%3E3.0.CO%3B2-W

Electron-affinic sensitization. VII. A correlation between structures, one-electron reduction potentials, and efficiencies of nitroimidazoles as hypoxic cell radiosensitizers

21 January 2018

1

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

Cancer chemotherapy reports

12 September 2023

2

58

559

Chapman

1974

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

Clinical phase I study of the hypoxic cell radiosensitizer RO-07-0582, a 2-nitroimidazole derivative

12 September 2023

6

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer

12 September 2023

7

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

Determination of metronidazole and misonidazole and their metabolites in plasma and urine by high-performance liquid chromatography

12 September 2023

8

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice

12 September 2023

10

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole

12 September 2023

13

1 reference

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

https://api.crossref.org/works/10.1002/1097-0142(19811015)48:8%3C1697::AID-CNCR2820480802%3E3.0.CO;2-W

12 September 2023

Identifiers

10.1002/1097-0142(19811015)48:8<1697::AID-CNCR2820480802>3.0.CO;2-W

1 reference

16 March 2018

1 reference

16 March 2018