LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. (Q50781580)

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10 March 2020

title

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression (English)

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Jo Vandesompele

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Lukas C Heukamp

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Rogier Versteeg

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Frank Speleman

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Huib N Caron

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Jan J Molenaar

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Raquel Domingo-Fernández

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Marli E Ebus

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Sven Lindner

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Ksenija Drabek

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language of work or name

English

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publication date

7 October 2012

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10 March 2020

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10 March 2020

volume

44

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issue

11

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10 March 2020

page(s)

1199-1206

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https://scigraph.springernature.com/pub.10.1038/ng.2436

10 March 2020

exact match

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cites work

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA

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Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency

21 January 2018

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LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

21 January 2018

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The Lin28/let-7 axis regulates glucose metabolism

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Induced pluripotent stem cell lines derived from human somatic cells

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Lin28 promotes transformation and is associated with advanced human malignancies

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Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma

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Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma

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LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer

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LIN28B promotes colon cancer progression and metastasis

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Genetic variation in LIN28B is associated with the timing of puberty

21 January 2018

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Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche

21 January 2018

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Selective blockade of microRNA processing by Lin28

21 January 2018

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MicroRNA maturation: stepwise processing and subcellular localization

21 January 2018

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

21 January 2018

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Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

21 January 2018

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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

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Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.

21 January 2018

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The let-7 family of microRNAs

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The tumor suppressor microRNA let-7 represses the HMGA2 oncogene

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Impaired microRNA processing enhances cellular transformation and tumorigenesis

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The let-7 microRNA represses cell proliferation pathways in human cells

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The role of let-7 in cell differentiation and cancer

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Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

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Let-7 expression defines two differentiation stages of cancer

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Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research

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Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

21 January 2018

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Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival

21 January 2018

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miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples

21 January 2018

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A genome-wide search for promoters that respond to increased MYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma

21 January 2018

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MYCN regulates oncogenic MicroRNAs in neuroblastoma

21 January 2018

1 reference

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

21 January 2018

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MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma

21 January 2018

1 reference

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

21 January 2018

1 reference

MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets

21 January 2018

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A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene

21 January 2018

1 reference

MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

21 January 2018

1 reference

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

21 January 2018

1 reference

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis.

21 January 2018

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

21 January 2018

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Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling.

21 January 2018

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

21 January 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

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MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2.

21 January 2018

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MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells

21 January 2018

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

21 January 2018

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Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

21 January 2018

1 reference

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b

21 January 2018

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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

21 January 2018

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Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell

21 January 2018

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A developmental timing switch promotes axon outgrowth independent of known guidance receptors

21 January 2018

1 reference

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

21 January 2018

1 reference

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma

21 January 2018

1 reference

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

21 January 2018

1 reference

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

21 January 2018

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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

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High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA.

21 January 2018

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A novel and universal method for microRNA RT-qPCR data normalization

21 January 2018

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Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

21 January 2018

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Cytohesins are cytoplasmic ErbB receptor activators

21 January 2018

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Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells

21 January 2018

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Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification

21 January 2018

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12 December 2020

A role for Lin28 in primordial germ-cell development and germ-cell malignancy

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12 December 2020

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma

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12 December 2020

Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.

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12 December 2020

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

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12 December 2020

PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells

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7 January 2021