ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets. (Q50858312)

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4 March 2020

title

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets (English)

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4 March 2020

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1 reference

3

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4 March 2020

author name string

Meike Vogler

series ordinal

1

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4 March 2020

David Dinsdale

series ordinal

2

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4 March 2020

Gerald M Cohen

series ordinal

4

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4 March 2020

language of work or name

English

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publication date

4 July 2013

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British Journal of Haematology

4 March 2020

published in

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volume

163

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4 March 2020

issue

1

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4 March 2020

page(s)

139-142

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The Bcl2 family: regulators of the cellular life-or-death switch

4 March 2020

cites work

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

1 reference

Programmed anuclear cell death delimits platelet life span.

21 January 2018

1 reference

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

21 January 2018

1 reference

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

21 January 2018

1 reference

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

1 reference

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.

21 January 2018

1 reference