E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in Merlin-negative malignant mesothelioma cells. (Q50973584)

26 March 2018

title

E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in Merlin-negative malignant mesothelioma cells. (English)

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26 March 2018

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T Kato

1

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26 March 2018

T Sato

series ordinal

2

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26 March 2018

K Yokoi

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3

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26 March 2018

Y Sekido

series ordinal

4

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26 March 2018

language of work or name

English

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publication date

29 May 2017

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26 March 2018

published in

Oncogene

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26 March 2018

volume

36

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26 March 2018

issue

39

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26 March 2018

page(s)

5522-5531

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26 March 2018

describes a project that uses

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Advances in malignant mesothelioma

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The global spread of asbestos

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Genomic abnormalities and signal transduction dysregulation in malignant mesothelioma cells

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Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma

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High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas

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Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.

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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

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A mouse model recapitulating molecular features of human mesothelioma

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https://api.crossref.org/works/10.1038%2FONC.2017.147

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2017.147

Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.

21 January 2018

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LATS2 is a tumor suppressor gene of malignant mesothelioma.

21 January 2018

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LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade

21 January 2018

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YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.

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Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation.

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Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing

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Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival

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Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling

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NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth

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Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

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Focal adhesion kinase: in command and control of cell motility

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FAK regulates biological processes important for the pathogenesis of cancer

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Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients

21 January 2018

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Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.

21 January 2018

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The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner

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PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

21 January 2018

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The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

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Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

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Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma.

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

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Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells

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Nuclear FAK: a new mode of gene regulation from cellular adhesions

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E-cadherin promotes proliferation of human ovarian cancer cells in vitro via activating MEK/ERK pathway.

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The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

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FAK integrates growth-factor and integrin signals to promote cell migration

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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

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The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

21 January 2018

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Regulation of cell-cell adhesion by the cadherin-catenin complex

21 January 2018

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The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex

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E-cadherin-integrin crosstalk in cancer invasion and metastasis

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Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target

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E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion.

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Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer.

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Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors

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Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.

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The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma

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Problems in mesothelioma diagnosis

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Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments

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Investigation of the freely available easy-to-use software 'EZR' for medical statistics

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Malignant mesothelioma

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Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells

31 March 2020

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E-cadherin, E-selectin and vascular cell adhesion molecule: immunohistochemical markers for differentiation between mesothelioma and metastatic pulmonary adenocarcinoma?

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Identifiers

DOI

10.1038/ONC.2017.147

1 reference

26 March 2018

Dimensions Publication ID

1085705513

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1 reference

26 March 2018