Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α. (Q51043726)

27 March 2018

title

Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α. (English)

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27 March 2018

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Keiichiro Matoba

1

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27 March 2018

Daiji Kawanami

2

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27 March 2018

Rina Okada

3

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27 March 2018

Masami Tsukamoto

4

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27 March 2018

Jun Kinoshita

5

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27 March 2018

Tomoko Ito

6

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27 March 2018

Sho Ishizawa

7

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27 March 2018

Yasushi Kanazawa

8

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27 March 2018

Tamotsu Yokota

9

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27 March 2018

Noriyuki Murai

10

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27 March 2018

Senya Matsufuji

11

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27 March 2018

Junko Takahashi-Fujigasaki

12

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27 March 2018

Kazunori Utsunomiya

13

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27 March 2018

language of work or name

English

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publication date

24 April 2013

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27 March 2018

published in

Kidney International

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27 March 2018

volume

84

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27 March 2018

issue

3

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27 March 2018

page(s)

545-554

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27 March 2018

https://scigraph.springernature.com/pub.10.1038/ki.2013.130

exact match

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cites work

Hypoxia promotes fibrogenesis in human renal fibroblasts

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Evidence of tubular hypoxia in the early phase in the remnant kidney model

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension.

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Renal diffusion and BOLD MRI in experimental diabetic nephropathy. Blood oxygen level-dependent

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Adaptation to hypoxia in the diabetic rat kidney

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Hypoxia-Inducible Factor-1 (HIF-1)

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Contribution of Rho A and Rho Kinase to Platelet-Derived Growth Factor-BB-Induced Proliferation of Vascular Smooth Muscle Cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Rho-kinase is an important therapeutic target in cardiovascular medicine

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

HIF-1α mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Impaired tubular uptake explains albuminuria in early diabetic nephropathy

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Hypoxic induction of Ctgf is directly mediated by Hif-1.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Regulation of pathways of glucose metabolism in the kidney. The activity of the pentose phosphate pathway, glycolytic route and the regulation of phosphofructokinase in the kidney of lean and genetically obese (ob/ob) mice; comparison with effects o

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Pathogenetic mechanisms of diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

HIF in kidney disease and development

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

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https://api.crossref.org/works/10.1038%2FKI.2013.130

7 January 2021

Identifiers

DOI

10.1038/KI.2013.130

1 reference

27 March 2018

release_qjn5zlo66rgq7cx6iciu7igowm

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/qjn5zlo66rgq7cx6iciu7igowm

24 November 2022

mapped directly with Wikidata item

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27 March 2018