Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS. (Q51067452)

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scientific article published on 15 July 2014

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English	Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS.	scientific article published on 15 July 2014

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10 March 2020

Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS (English)

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10 March 2020

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Jean-Pierre Timmermans

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10 March 2020

Adam Cygankiewicz

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10 March 2020

Piotr K Zakrzewski

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10 March 2020

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10 March 2020

Nathalie Vergnolle

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10 March 2020

Ewa Malecka-Panas

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10 March 2020

Wanda Małgorzata Krajewska

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10 March 2020

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J Fichna

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M Sobczak

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10 March 2020

A Mokrowiecka

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10 March 2020

M Sałaga

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10 March 2020

M Storr

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10 March 2020

publication date

15 July 2014

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10 March 2020

Neurogastroenterology and Motility

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10 March 2020

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10 March 2020

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10 March 2020

1539-1550

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10 March 2020

Brain-Gut Interactions in IBS

1 reference

https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Inhibition of proteases as a novel therapeutic strategy in the treatment of metabolic, inflammatory and functional diseases of the gastrointestinal tract

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https://api.crossref.org/works/10.1111%2FNMO.12390

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Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

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cDNA cloning of an orphan opiate receptor gene family member and its splice variant

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https://api.crossref.org/works/10.1111%2FNMO.12390

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Cloning, expression and functional role of a nociceptin/orphanin FQ receptor in the porcine gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Functional role and sequence analysis of a lymphocyte orphan opioid receptor

1 reference

https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells.

1 reference

https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines

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Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.

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Nociceptin/orphanin FQ modulates spatial learning via ORL-1 receptors in the dorsal hippocampus of the rat.

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21 January 2018

Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation.

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21 January 2018

Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4

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21 January 2018

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

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https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

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21 January 2018

Nociceptin / orphanin FQ (NOP) receptors as novel potential target in the treatment of gastrointestinal diseases

1 reference

https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats.

1 reference

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21 January 2018

Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ.

1 reference

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21 January 2018

Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/μ receptor agonists in the sciatic nerve ligation chronic pain model in mice

1 reference

https://api.crossref.org/works/10.1111%2FNMO.12390

21 January 2018

Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder

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21 January 2018

Recently patented and promising ORL-1 ligands: where have we been and where are we going?

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21 January 2018

The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).

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21 January 2018

Anti-inflammatory and antinociceptive action of an orally available nociceptin receptor agonist SCH 221510 in a mouse model of inflammatory bowel diseases

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21 January 2018

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

1 reference

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21 January 2018

NOP Receptor Ligands as Potential Agents for Inflammatory and Autoimmune Diseases.

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21 January 2018

Characterization of nociceptin hyperalgesia and allodynia in conscious mice

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21 January 2018

Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: involvement of inflammatory mediators

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21 January 2018

Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphaninFQ in rats

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21 January 2018

Orphanin FQ causes contractions via inhibiting purinergic pathway in the rat colon

1 reference

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21 January 2018

Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

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21 January 2018

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

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21 January 2018

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

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21 January 2018

Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray.

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21 January 2018

Buprenorphine for neuropathic pain--targeting hyperalgesia

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21 January 2018

Central and peripheral role of the nociceptinorphaninFQ system on normal and disturbed colonic motor function and faecal pellet output in the rat

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21 January 2018

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