MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. (Q51115513)

30 March 2018

title

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. (English)

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30 March 2018

author name string

Matechak EO

1

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30 March 2018

Killeen N

2

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30 March 2018

Hedrick SM

3

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30 March 2018

Fowlkes BJ

4

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30 March 2018

language of work or name

English

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publication date

1 April 1996

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30 March 2018

published in

Immunity

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30 March 2018

volume

4

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30 March 2018

issue

4

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30 March 2018

page(s)

337-347

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30 March 2018

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

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Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection

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Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

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Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice.

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Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection

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Another view of the selective model of thymocyte selection.

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7 January 2021

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity.

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7 January 2021

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages

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7 January 2021

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

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7 January 2021

Positive selection of T cells

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7 January 2021

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

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7 January 2021

Mice lacking major histocompatibility complex class I and class II molecules

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7 January 2021

Stochastic component to development of class I major histocompatibility complex-specific T cells

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7 January 2021

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

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7 January 2021

Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes

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7 January 2021

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

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7 January 2021

Helper T-cell development in the absence of CD4-p56 Ick association

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7 January 2021

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

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7 January 2021

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

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7 January 2021

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

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Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

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Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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7 January 2021

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

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7 January 2021

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

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7 January 2021

Cytotoxic monoclonal antibody specific for the Lyt-1.2 antigen

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7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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7 January 2021

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

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7 January 2021

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

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7 January 2021

Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice

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7 January 2021

Evidence for differential intracellular signaling via CD4 and CD8 molecules

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7 January 2021

Selective events in T cell development

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7 January 2021

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.

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7 January 2021

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

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7 January 2021

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

1 reference

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7 January 2021

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice.

1 reference

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7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980247-2

7 January 2021

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

1 reference

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7 January 2021

Development of mature CD8+ thymocytes: selection rather than instruction?

1 reference

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7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

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7 January 2021

The selection of the α,β heterodimeric T-cell receptor for antigen.

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7 January 2021

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

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7 January 2021

The structure of V alpha and J alpha segments in the mouse

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7 January 2021

10.1016/S1074-7613(00)80247-2

Identifiers

DOI

1 reference

30 March 2018

PubMed ID

8612128

1 reference

30 March 2018