Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. (Q51176113)

31 March 2018

title

Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. (English)

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31 March 2018

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Rongkui Zhou

1

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31 March 2018

Zhaohong Wang

series ordinal

2

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31 March 2018

Chao Ma

series ordinal

3

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31 March 2018

publication date

1 June 2014

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31 March 2018

Cell Biochemistry and Biophysics

published in

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31 March 2018

volume

69

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31 March 2018

issue

2

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31 March 2018

page(s)

311-317

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31 March 2018

https://scigraph.springernature.com/pub.10.1007/s12013-013-9800-8

exact match

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Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway.

21 January 2018

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The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects

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Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals

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Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).

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Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation

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Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-κB and NFATc1 pathways.

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(-)-Epigallocathechin-3-gallate, an AMPK activator, decreases ovariectomy-induced bone loss by suppression of bone resorption.

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10.1007/S12013-013-9800-8

21 January 2018

Identifiers

DOI

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31 March 2018

PubMed ID

24338527

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31 March 2018