Hairy Dmel_CG6494 (Q51236144)

http://www.ebi.ac.uk/interpro/protein/P14003

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

11 references

9 May 2019

Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Physical and genetic interactions link hox function with diverse transcription factors and cell signaling proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

transcription factor binding

IPI

1 reference

9 May 2019

Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

protein dimerization activity

IPI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

1 reference

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IDA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

DNA-binding transcription repressor activity, RNA polymerase II-specific

4 references

10 September 2018

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

transcription corepressor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

sequence-specific DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

sequence-specific double-stranded DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

negative regulation of transcription by RNA polymerase II

biological process

6 references

7 November 2018

Runt and Lozenge function in Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

7 November 2018

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

7 November 2018

Origins of context-dependent gene repression by capicua

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

7 November 2018

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

7 November 2018

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

7 November 2018

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

1 reference

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

1 reference

9 May 2019

Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

transcription, DNA-templated

IMP

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

periodic partitioning by pair rule gene

4 references

9 May 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

The origin and evolution of segmentation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Playing by pair-rules?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

nervous system development

1 reference

9 May 2019

The role of class I HLH genes in neural development--have they been overlooked?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

open tracheal system development

TAS

1 reference

9 May 2019

A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

salivary gland morphogenesis

IMP

3 references

9 May 2019

Constructing an organ: the Drosophila salivary gland as a model for tube formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

IGI

R8 cell fate commitment

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P14003&geneProductId=UniProtKB:P14003

regulation of cellular metabolic process

NAS

1 reference

9 May 2019

Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

1 reference

9 May 2019

Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

posterior head segmentation

IMP

1 reference

9 May 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

1 reference

9 May 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

negative regulation of transcription, DNA-templated

TAS

4 references

9 May 2019

Transcriptional repression: the long and the short of it.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

Tube morphogenesis: no pipe dream in Drosophila

IDA

membrane organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Notch signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

regulation of neurogenesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

negative regulation of transcription by RNA polymerase II

5 references

8 April 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

8 April 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

8 April 2019

Origins of context-dependent gene repression by capicua

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

8 April 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

8 April 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

negative regulation of transcription by RNA polymerase II

IDA

6 references

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Origins of context-dependent gene repression by capicua

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P14003

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P14003

Orange domain

1 reference

stated in

InterPro Release 71.0