Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. (Q51348965)

4 April 2018

title

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. (English)

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4 April 2018

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3

Raimund J Ober

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4 April 2018

E. Sally Ward

series ordinal

4

object named as

E Sally Ward

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4 April 2018

author name string

Carlos Vaccaro

series ordinal

1

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4 April 2018

Jinchun Zhou

series ordinal

2

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4 April 2018

publication date

25 September 2005

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4 April 2018

published in

Nature Biotechnology

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4 April 2018

volume

23

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4 April 2018

issue

10

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4 April 2018

page(s)

1283-1288

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4 April 2018

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Pathology of lupus nephritis

21 January 2018

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Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

21 January 2018

1 reference

Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells

21 January 2018

1 reference

FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells

21 January 2018

1 reference

Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung

21 January 2018

1 reference

Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.

21 January 2018

1 reference

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

21 January 2018

1 reference

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

21 January 2018

1 reference

Receptor-mediated transport of IgG

21 January 2018

1 reference

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

21 January 2018

1 reference

Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants.

21 January 2018

1 reference

The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn

21 January 2018

1 reference

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

21 January 2018

1 reference

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

Increasing the serum persistence of an IgG fragment by random mutagenesis.

21 January 2018

1 reference

Engineered human IgG antibodies with longer serum half-lives in primates

21 January 2018

1 reference

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

21 January 2018

1 reference

Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G.

21 January 2018

1 reference

Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

21 January 2018

1 reference

Immune pathophysiology of autoimmune thrombocytopenic purpura

21 January 2018

1 reference

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans

21 January 2018

1 reference

Fc receptors and their role in immune regulation and autoimmunity

21 January 2018

1 reference

Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor

21 January 2018

1 reference

Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies

21 January 2018

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Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

21 January 2018

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Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site-directed mutagenesis.

21 January 2018

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Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1.

21 January 2018

1 reference

Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution

21 January 2018

1 reference

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution

21 January 2018

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Recombinant antibodies for cancer diagnosis and therapy

21 January 2018

1 reference

7 January 2021

Isolation and characterization of an Fc receptor from neonatal rat small intestine

1 reference

7 January 2021

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

1 reference

7 January 2021

Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn

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7 January 2021

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

1 reference

7 January 2021

Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect

1 reference

7 January 2021

Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases

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7 January 2021

Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis

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7 January 2021

Antibody framework residues affecting the conformation of the hypervariable loops

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7 January 2021

Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells.

1 reference

7 January 2021

Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT1143

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4 April 2018

release_s6ug5kjr7fcjhi6rkp36agq6yy

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/s6ug5kjr7fcjhi6rkp36agq6yy

24 November 2022

mapped directly with Wikidata item

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4 April 2018