SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain. (Q51414552)

5 April 2018

title

SYM-2081 a kainate receptor antagonist reduces allodynia and hyperalgesia in a freeze injury model of neuropathic pain. (English)

1 reference

5 April 2018

0 references

Ta LE

1

1 reference

5 April 2018

Dionne RA

2

1 reference

5 April 2018

Fricton JR

3

1 reference

5 April 2018

Hodges JS

4

1 reference

5 April 2018

Kajander KC

5

1 reference

5 April 2018

language of work or name

English

0 references

publication date

1 March 2000

1 reference

5 April 2018

published in

Brain Research

1 reference

5 April 2018

volume

858

1 reference

5 April 2018

issue

1

1 reference

5 April 2018

page(s)

106-120

1 reference

5 April 2018

The primary afferent depolarizing action of kainate in the rat.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Spike-evoked suppression and burst patterning in dorsal root ganglion neurons of the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Induced hypothermia in peripheral nerve: electron microscopic and electrophysiological observations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to monkey's face

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Review: neurotransmitter receptors. II. AMPA and kainate receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Behavioural and neurochemical interactions of the AMPA antagonist GYKI 52466 and the non-competitive NMDA antagonist dizocilpine in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Role of substance P in the modulation of C-fiber-evoked responses of spinal dorsal horn neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Sensitization of unmyelinated nociceptive afferents in monkey varies with skin type

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Selective changes of receptive field properties of spinal nociceptive neurones induced by noxious visceral stimulation in the cat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Regulation of glutamate release by presynaptic kainate receptors in the hippocampus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The pathology of injury to nerve induced by cold

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Nerve pathophysiology and mechanisms of pain in causalgia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Neuropathic pain and injured nerve: Peripheral mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Reorganisation of spinal cord sensory map after peripheral nerve injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Supraspinal inhibition of the excitation of dorsal horn neurones by impulses in unmyelinated primary afferents: Lack of effect by strychnine and bicuculline

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Peripheral nerve regeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

New developments in the molecular pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and kainate receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Alterations in myelinated fibres in the sciatic nerve of rats after constriction: possible relationships between the presence of abnormal small myelinated fibres and pain-related behaviour

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Baclofen reverses the hypersensitivity of dorsal horn wide dynamic range neurons to mechanical stimulation after transient spinal cord ischemia; implications for a tonic GABAergic inhibitory control of myelinated fiber input

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Cloning by functional expression of a member of the glutamate receptor family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

An immunohistochemical study of neuronal populations containing neuropeptides or gamma-aminobutyrate within the superficial layers of the rat dorsal horn

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Excitatory amino acid receptor-mediated neuronal signal transduction: modulation by polyamines and calcium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Long-term patterns of axon regeneration in the sciatic nerve and its tributaries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Evaluation of hindpaw position in rats during chronic constriction injury (CCI) produced with different suture materials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Involvement of increased excitatory amino acids and intracellular Ca2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Comparison of three rodent neuropathic pain models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Dynamic and static components of mechanical hyperalgesia in human hairy skin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

A time course analysis of the changes in spontaneous and evoked behaviour in a rat model of neuropathic pain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Nerve Degeneration Following Prolonged Cooling of an Extremity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Glutamate receptors of the kainate type and synaptic transmission

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The physiology of excitatory amino acids in the vertebrate central nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Excitatory amino acid neurotoxicity and neurodegenerative disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Pain mechanisms: a new theory

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Involvement of substance P and excitatory amino acids in aversive behavior elicited by intrathecal capsaicin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Spatial and temporal transformations of input to spinothalamic tract neurons and their relation to somatic sensations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

GABAergic mechanisms of analgesia: an update

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Peripheral Nerve Damage by Cold

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Amino acids and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injections

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Behavioral sensitization to kainic acid and quisqualic acid in mice: comparison to NMDA and substance P responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

A classification of peripheral nerve injuries producing loss of function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Causalgia: Redefinition as a clinical pain syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Experiments on the Section of the Glossopharyngeal and Hypoglossal Nerves of the Frog, and Observations of the Alterations Produced Thereby in the Structure of Their Primitive Fibres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Excitatory Amino Acid Transmitters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Activation and desensitization of hippocampal kainate receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The behavioral pharmacology of NMDA receptor antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Evidence for a central component of post-injury pain hypersensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Ethical guidelines for investigations of experimental pain in conscious animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

Cutaneous polymodal receptors: characteristics and plasticity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-8993%2899%2902437-3

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-8993(99)02437-3

1 reference

5 April 2018

1 reference

5 April 2018