Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance. (Q51452446)

5 April 2018

title

Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance. (English)

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5 April 2018

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Kharasch ED

1

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Jubert C

2

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Senn T

3

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Bowdle TA

4

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Thummel KE

5

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publication date

1 July 1999

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The Journal of Clinical Pharmacology

published in

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volume

39

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issue

7

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page(s)

664-669

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The human drug metabolizing cytochromes P450.

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

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Physiologic and temporal variation in hepatic elimination of midazolam.

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Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam.

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The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

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No evidence of a genetic polymorphism in the oxidative metabolism of midazolam.

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Quantitation of three-month intraindividual variability and influence of sex and menstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidase activity determined with caffeine phenotyping

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

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Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance

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10.1177/00912709922008290

21 January 2018

Identifiers

DOI

1 reference

5 April 2018

release_5xaoernakfbctlvhxlqrv3nawe

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5xaoernakfbctlvhxlqrv3nawe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

5 April 2018