Collagen type III alpha 1 chain (Q5145885)

randomized controlled trial

Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial

clinical trial

Collagenase clostridium histolyticum for the treatment of Peyronie's disease: a prospective Italian multicentric study

clinical trial

Collagenase injections for Dupuytren's contracture: prospective cohort study in a public health setting

review article

Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases.

1 reference

18 December 2019

1 reference

18 December 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

2 references

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

4 references

8 April 2019

Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

platelet-derived growth factor binding

IPI

1 reference

8 April 2019

Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

extracellular matrix structural constituent

3 references

17 October 2017

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

1 reference

8 April 2019

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

extracellular matrix structural constituent

IPI

4 references

8 April 2019

Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

extracellular matrix structural constituent conferring tensile strength

IBA

4 references

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

extracellular matrix structural constituent conferring tensile strength

HDA

10 references

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

extracellular matrix structural constituent conferring tensile strength

5 references

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

endoplasmic reticulum lumen

HDA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

3 references

17 October 2017

Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

G to T transversion at position +5 of a splice donor site causes skipping of the preceding exon in the type III procollagen transcripts of a patient with Ehlers-Danlos syndrome type IV

collagen type III trimer

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

5 references

17 October 2017

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

17 October 2017

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

3 references

collagen type III trimer

6 references

8 April 2019

G to T transversion at position +5 of a splice donor site causes skipping of the preceding exon in the type III procollagen transcripts of a patient with Ehlers-Danlos syndrome type IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

RNAi-mediated inhibition of COL1A1 and COL3A1 in human skin fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

3 references

8 April 2019

Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

collagen-containing extracellular matrix

IBA

9 references

8 April 2019

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Abnormal type III collagen produced by an exon-17-skipping mutation of the COL3A1 gene in Ehlers-Danlos syndrome type IV is not incorporated into the extracellular matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

skeletal system development

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

extracellular matrix organization

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

1 reference

8 April 2019

Simple collagen-like peptides support platelet adhesion under static but not under flow conditions: interaction via alpha2 beta1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 reference

8 April 2019

Myocardial infarction resulting from coronary artery dissection in an adolescent with Ehlers-Danlos syndrome type IV due to a type III collagen mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

peptide cross-linking

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

negative regulation of immune response

1 reference

8 April 2019

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

blood vessel development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

regulation of immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

collagen catabolic process

TAS

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02461&geneProductId=UniProtKB:P02461

cellular response to amino acid stimulus

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

integrin-mediated signaling pathway

1 reference

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

The effects of single doses of beta radiation on the wound healing behaviour of human Tenon's capsule fibroblasts

response to radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 reference

8 April 2019

A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

digestive tract development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

aorta smooth muscle tissue morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

1 reference

8 April 2019

Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

collagen fibril organization

4 references

8 April 2019

G to T transversion at position +5 of a splice donor site causes skipping of the preceding exon in the type III procollagen transcripts of a patient with Ehlers-Danlos syndrome type IV

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Mutations in the COL3A1 gene result in the Ehlers-Danlos syndrome type IV and alterations in the size and distribution of the major collagen fibrils of the dermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Myocardial infarction resulting from coronary artery dissection in an adolescent with Ehlers-Danlos syndrome type IV due to a type III collagen mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

2 references

8 April 2019

The effects of single doses of beta radiation on the wound healing behaviour of human Tenon's capsule fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

8 April 2019

Collagen types I and III propeptides as markers of healing in chronic leg ulcers. A noninvasive method for the determination of procollagen propeptides in wound fluid--influence of growth hormone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

supramolecular fiber organization

1 reference

8 April 2019

Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 Instead of alpha5beta1 integrin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02461

physically interacts with

ocriplasmin

object of statement has role

hydrolase

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2095222

Gene Atlas image

PBB GE COL3A1 211161 s at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P02461

1 reference

Fibrillar collagen, C-terminal

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02461

VWFC domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02461

Collagen triple helix repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02461

Identifiers

1 reference

27 December 2019

1 reference

18 December 2019

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016

1 reference

29 June 2016