Concentration-dependent metabolism of diazepam in mouse liver. (Q51601483)

7 April 2018

title

Concentration-dependent metabolism of diazepam in mouse liver. (English)

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7 April 2018

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M V St-Pierre

1

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7 April 2018

K S Pang

series ordinal

2

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7 April 2018

publication date

1 June 1995

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Journal of Pharmacokinetics and Pharmacodynamics

published in

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volume

23

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issue

3

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page(s)

243-266

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https://scigraph.springernature.com/pub.10.1007/bf02354284

exact match

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cites work

Further studies on species difference in diazepam metabolism

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Metabolism and anticonvulsant activity of diazepam in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Effect of phenobarbital on the in vitro metabolism of diazepam in several animal species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Diazepam metabolites in the rat: Characterization by high-resolution mass spectrometry and nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Metabolism of diazepam and related benzodiazepines by human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Inhibition of diazepam metabolism in microsomal- and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Comparison of cytochrome P-450 content and activities in liver microsomes of seven animal species, including man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

The metabolism of diazepam by liver microsomal enzymes of rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Dizepam metabolism in human foetal and adult liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Statistical moment theory in chemical kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

In vitro and in vivo assessment of hepatic and extrahepatic metabolism of diazepam in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Protein binding and hepatic clearance: discrimination between models of hepatic clearance with diazepam, a drug of high intrinsic clearance, in the isolated perfused rat liver preparation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354284

Selenium and drug metabolism--I. Multiple modulations of mouse liver enzymes

21 January 2018

1 reference

12 December 2020

Kinetics of sequential metabolism. Contribution of parallel, primary metabolic pathways to the formation of a common, secondary metabolite.

1 reference

12 December 2020

IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTION

1 reference

12 December 2020

The metabolic disposition of oxazepam in rats.

1 reference

12 December 2020

Interaction of uridine 5‘-diphosphoglucuronic acid (UDPGA) with cytochrome P 450

1 reference

12 December 2020

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

12 December 2020

Physical partitioning as the major source of metoprolol uptake by hepatic microsomes

1 reference

12 December 2020

Metabolism of diazepam in vitro by human liver. Independent variability of N-demethylation and C3-hydroxylation.

1 reference

12 December 2020

Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat

1 reference

12 December 2020

Study of physiological availability of temazepam in man

1 reference

12 December 2020

Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation

1 reference

12 December 2020

Diazepam metabolism during chronic medication unbound fraction in plasma, erythrocytes and urine

1 reference

12 December 2020

Metabolism of diazepam in rat, dog, and man.

1 reference

12 December 2020

Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver.

1 reference

12 December 2020

Competition between two enzymes for substrate removal in liver: modulating effects due to substrate recruitment of hepatocyte activity

1 reference

12 December 2020

Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.

1 reference

12 December 2020

A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination

1 reference

12 December 2020

Determination of drug metabolizing enzymes in needle biopsies of human liver

1 reference

12 December 2020

Sequential metabolism of salicylamide exclusively to gentisamide 5-glucuronide and not gentisamide sulfate conjugates in single-pass in situ perfused rat liver

1 reference

12 December 2020

The metabolic fate of oxazepam in mice

1 reference

12 December 2020

The biotransformation of oxazepam (7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one) in man, miniature swine and rat

1 reference

12 December 2020

Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver.

1 reference

12 December 2020

Determination of diazepam and its metabolites by high-performance liquid chromatography and thin-layer chromatography

1 reference

12 December 2020

Tissue distribution of 14C-diazepam and its metabolites in rats.

1 reference

12 December 2020

A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02354284

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7 April 2018

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7 April 2018