A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. (Q51752480)

11 April 2018

title

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. (English)

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11 April 2018

autosomal recessive polycystic kidney

main subject

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author name string

Woollard JR

1

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Punyashtiti R

2

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Richardson S

3

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Masyuk TV

4

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Whelan S

5

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Huang BQ

6

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Lager DJ

7

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vanDeursen J

8

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Torres VE

9

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Gattone VH

10

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LaRusso NF

11

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Harris PC

12

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Ward CJ

13

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language of work or name

English

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publication date

23 May 2007

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11 April 2018

published in

Kidney International

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volume

72

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issue

3

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page(s)

328-336

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Autosomal recessive polycystic kidney disease

cites work

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Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease

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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

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PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

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The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

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Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

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7 January 2021

Identifiers

DOI

10.1038/SJ.KI.5002294

1 reference

11 April 2018

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11 April 2018