Fumarylacetoacetate hydrolase (Q517790)

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mammalian protein found in Homo sapiens

• fumarylacetoacetase
• epididymis secretory sperm binding protein
• FAA
• beta-diketonase
• fumarylacetoacetate hydrolase (fumarylacetoacetase)
• FAH

edit

Language	Label	Description	Also known as
English	Fumarylacetoacetate hydrolase	mammalian protein found in Homo sapiens	fumarylacetoacetase epididymis secretory sperm binding protein FAA beta-diketonase fumarylacetoacetate hydrolase (fumarylacetoacetase) FAH

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16930

part of

Fumarylacetoacetase-like, C-terminal domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16930

Fumarylacetoacetase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16930

Fumarylacetoacetase, N-terminal domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16930

Fumarylacetoacetase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fumarylacetoacetase-like, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16930

encoded by

FAH

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16930

molecular function

fumarylacetoacetase activity

determination method

EXP

IEA

TAS

5 references

retrieved

26 September 2017

stated in

Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

26 September 2017

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

26 September 2017

stated in

Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

EXP

protein binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IPI

catalytic activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

hydrolase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

fumarylacetoacetase activity

determination method

EXP

IBA

IEA

TAS

6 references

retrieved

1 January 2018

stated in

Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

1 January 2018

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

1 January 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

1 January 2018

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IBA

retrieved

1 January 2018

stated in

Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

EXP

fumarylacetoacetase activity

determination method

IBA

IEA

TAS

5 references

retrieved

8 April 2019

stated in

Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IBA

cell component

cytosol

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

TAS

extracellular exosome

determination method

IDA

3 references

retrieved

26 September 2017

stated in

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IDA

retrieved

26 September 2017

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IDA

retrieved

26 September 2017

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IDA

cytosol

determination method

IBA

TAS

2 references

retrieved

1 January 2018

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

1 January 2018

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IBA

extracellular exosome

determination method

HDA

2 references

retrieved

8 April 2019

stated in

Large-scale proteomics and phosphoproteomics of urinary exosomes

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

HDA

retrieved

8 April 2019

stated in

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

HDA

biological process

aromatic amino acid family metabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

metabolism

determination method

IEA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

L-phenylalanine catabolic process

determination method

IEA

TAS

2 references

retrieved

26 September 2017

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

arginine catabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

tyrosine catabolic process

determination method

IEA

TAS

2 references

retrieved

26 September 2017

stated in

Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16930&geneProductId=UniProtKB:P16930

determination method

IEA

L-phenylalanine catabolic process

determination method

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IBA

tyrosine catabolic process

determination method

IBA

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P16930

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IEA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IBA

homogentisate catabolic process

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16930

determination method

IBA

Gene Atlas image

PBB GE FAH 202862 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P16930

1 reference

stated in

Identifiers.org

has part(s)

Fumarylacetoacetase-like, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16930

Fumarylacetoacetase, N-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P16930

Identifiers

RefSeq protein ID

NP_000128

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2184

NP_001361306

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2184

NP_001361309

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2184

UniProt protein ID

P16930

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P16930

Ensembl protein ID

ENSP00000261755

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000261755

ENSP00000385080

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000385080

ENSP00000453347

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453347

ENSP00000453152

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453152

ENSP00000454952

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000454952

Freebase ID

/m/02rcwly

0 references

Microsoft Academic ID

2778985632

0 references

PDB structure ID

1HYO

1 reference

stated in

Swiss-Prot

UniProt

retrieved

9 November 2015

reference URL

http://www.uniprot.org/uniprot/P35505.txt?version=133

1QCN

1 reference

stated in

Swiss-Prot

UniProt

retrieved

9 November 2015

reference URL

http://www.uniprot.org/uniprot/P35505.txt?version=133

1QCO

1 reference

stated in

Swiss-Prot

UniProt

retrieved

9 November 2015

reference URL

http://www.uniprot.org/uniprot/P35505.txt?version=133

1QQJ

1 reference

stated in

Swiss-Prot

UniProt

retrieved

9 November 2015

reference URL

http://www.uniprot.org/uniprot/P35505.txt?version=133

2HZY

1 reference

stated in

Swiss-Prot

UniProt

retrieved

9 November 2015

reference URL

http://www.uniprot.org/uniprot/P35505.txt?version=133

 

Sitelinks

Wikipedia(10 entries)

edit

• bswiki FAH (gen)
• dewiki Fumarylacetoacetase
• enwiki Fumarylacetoacetate hydrolase
• hywiki Ֆումարիլացետոացետատ հիդրոլազ
• jawiki フマリルアセトアセターゼ
• shwiki Fumarilacetoacetaza
• srwiki Fumarilacetoacetaza
• ttwiki FAH
• ukwiki FAH
• zhwiki 延胡索醯乙醯乙酸水解酶

Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

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Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q517790&oldid=2022902435"