Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma. (Q51782637)

12 April 2018

title

Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma. (English)

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8

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Marina Konopleva

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Marina Konopleva

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6

Michael Andreeff

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1

Yoko Tabe

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Linhua Jin

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Linhua Jin

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Masato Shikami

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Masato Shikami

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Shinya Kimura

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Shinya Kimura

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author name string

Mark Raffeld

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publication date

19 September 2013

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published in

Acta Haematologica

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volume

131

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issue

1

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page(s)

59-69

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Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma

cites work

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12 December 2020

Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice

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12 December 2020

B cell receptor signaling: picky about PI3Ks

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12 December 2020

Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519).

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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

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The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

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Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

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12 December 2020

High frequency of mutations of the PIK3CA gene in human cancers

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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

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12 December 2020

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

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12 December 2020

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

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12 December 2020

Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

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12 December 2020

Advances in development of phosphatidylinositol 3-kinase inhibitors

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12 December 2020

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

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12 December 2020

Recognizing and exploiting differences between RNAi and small-molecule inhibitors

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12 December 2020

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

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12 December 2020

Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.

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12 December 2020

Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis

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12 December 2020

Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement

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12 December 2020

Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma

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12 December 2020

Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma

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12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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12 December 2020

In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).

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12 December 2020

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma

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p110δ, a novel phosphoinositide 3-kinase in leukocytes

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Establishment and characterization of a mantle cell lymphoma cell line

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12 December 2020

PML-RARalpha is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival

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12 December 2020

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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12 December 2020

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

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12 December 2020

Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach

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Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

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12 December 2020

Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene

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12 December 2020

Identifiers

DOI

10.1159/000353164

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