Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure. (Q51784372)

12 April 2018

title

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure. (English)

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9

Adria Giacca

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Loretta Lam

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object named as

Loretta Lam

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author name string

Tracy T Goh

1

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Timothy M Mason

2

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Neehar Gupta

3

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Abby So

4

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Tony K T Lam

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Gary F Lewis

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Andrea Mari

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publication date

26 September 2006

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American Journal of Physiology - Endocrinology and Metabolism

published in

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volume

292

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page(s)

E549-60

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issue

2

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Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose

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Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

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Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats

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Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1.

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Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes

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Fatty acid inhibition of glucose-stimulated insulin secretion is enhanced in pancreatic islets from insulin-resistant rats.

21 January 2018

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More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling

21 January 2018

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Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect

21 January 2018

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Non-esterified fatty acids are deleterious for human pancreatic islet function at physiological glucose concentration.

21 January 2018

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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis

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A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat.

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Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.

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Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

21 January 2018

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

21 January 2018

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Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.

21 January 2018

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A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

21 January 2018

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Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

21 January 2018

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Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9).

21 January 2018

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Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture

21 January 2018

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Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose

21 January 2018

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Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion

21 January 2018

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Assessment of insulin secretion in relation to insulin resistance

21 January 2018

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Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests

21 January 2018

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Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats

21 January 2018

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Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

21 January 2018

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Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes.

21 January 2018

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Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

21 January 2018

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Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjects

21 January 2018

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Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans

21 January 2018

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Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

21 January 2018

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Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells

21 January 2018

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

21 January 2018

1 reference

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10.1152/AJPENDO.00255.2006

21 January 2018

Identifiers

DOI

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12 April 2018

PubMed ID

17003242

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12 April 2018