The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding. (Q51799660)

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title

The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding. (English)

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author name string

Ki Won Kim

1

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Zhulun Wang

2

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James Busby

3

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Trace Tsuruda

4

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Michelle Chen

5

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Clarence Hale

6

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Víctor M Castro

7

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Stefan Svensson

8

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Rebecca Nybo

9

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Fei Xiong

10

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Minghan Wang

11

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language of work or name

English

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publication date

8 February 2007

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published in

FEBS Letters

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volume

581

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issue

5

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page(s)

995-999

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11beta-hydroxysteroid dehydrogenase: unexpected connections

cites work

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Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase

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The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane

21 January 2018

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The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome

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11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

21 January 2018

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Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

21 January 2018

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Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

21 January 2018

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A transgenic model of visceral obesity and the metabolic syndrome

21 January 2018

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Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex

21 January 2018

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Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species

21 January 2018

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11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase

21 January 2018

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The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2007.01.075

Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation

21 January 2018

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Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes

21 January 2018

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In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I

21 January 2018

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Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species

21 January 2018

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21 January 2018

Identifiers

DOI

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12 April 2018

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12 April 2018