Continuing strategies for inhibiting Alzheimer's gamma-secretase. (Q51843477)

13 April 2018

title

Continuing strategies for inhibiting Alzheimer's gamma-secretase. (English)

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13 April 2018

author name string

Michael S Wolfe

series ordinal

1

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13 April 2018

William P Esler

series ordinal

2

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13 April 2018

Chittaranjan Das

series ordinal

3

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13 April 2018

publication date

1 August 2002

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13 April 2018

Journal of Molecular Neuroscience

published in

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13 April 2018

volume

19

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13 April 2018

issue

1-2

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13 April 2018

page(s)

83-87

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13 April 2018

https://scigraph.springernature.com/pub.10.1007/s12031-002-0015-5

exact match

0 references

cites work

Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere

1 reference

12 December 2020

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 December 2020

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

12 December 2020

The Role of presenilins in gamma-secretase activity

1 reference

12 December 2020

HIV protease: a novel chemotherapeutic target for AIDS.

1 reference

12 December 2020

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

12 December 2020

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

1 reference

12 December 2020

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

HIV-protease inhibitors

1 reference

12 December 2020

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

12 December 2020

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

12 December 2020

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

12 December 2020

1 reference

12 December 2020

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

12 December 2020

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

12 December 2020

Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism

1 reference

12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020

10.1007/S12031-002-0015-5

Identifiers

DOI

1 reference

13 April 2018

release_raspccyuqjhulctq7ozrnhbgsa

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/raspccyuqjhulctq7ozrnhbgsa

24 November 2022

mapped directly with Wikidata item

PubMed ID

12212799

1 reference

13 April 2018