Cyclin dependent kinase 4 (Q5198250)

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mammalian protein found in Homo sapiens
  • PSK-J3
  • cyclin-dependent kinase 4
  • CDK4
  • cell division protein kinase 4
edit
Language Label Description Also known as
English
Cyclin dependent kinase 4
mammalian protein found in Homo sapiens
  • PSK-J3
  • cyclin-dependent kinase 4
  • CDK4
  • cell division protein kinase 4

Statements

molecular function
protein binding
determination method
IPI
47 references
retrieved
1 January 2018
stated in
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
GOA
curator
UniProt
UniProt protein ID
P11802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Novel insights into the INK4-CDK4/6-Rb pathway: counter action of gankyrin against INK4 proteins regulates the CDK4-mediated phosphorylation of Rb
GOA
curator
UniProt
UniProt protein ID
P11802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity
GOA
curator
UniProt
UniProt protein ID
P11802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin-binding motifs are essential for the function of p21CIP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Self-assembling protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
New functional activities for the p21 family of CDK inhibitors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
C-terminal phosphorylation controls the stability and function of p27kip1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Crystal structure of human CDK4 in complex with a D-type cyclin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Shifted Transversal Design smart-pooling for high coverage interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Interaction between Cdc37 and Cdk4 in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
The structure of CDK4/cyclin D3 has implications for models of CDK activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Functional characterization of human PFTK1 as a cyclin-dependent kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Proteomic analysis of p16ink4a-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
retrieved
1 January 2018
stated in
Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11802
determination method
IPI
cyclin-dependent protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
TAS
6 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11802&geneProductId=UniProtKB:P11802
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P11802
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11802&geneProductId=UniProtKB:P11802
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11802&geneProductId=UniProtKB:P11802
determination method
IEA
retrieved
1 January 2018
stated in
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11802&geneProductId=UniProtKB:P11802
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11802&geneProductId=UniProtKB:P11802
determination method
IBA
retrieved
1 January 2018
stated in
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11802&geneProductId=UniProtKB:P11802
determination method
EXP
cell component
biological process
Gene Atlas image
PBB GE CDK4 202246 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051358
subject named as
Cyclin-Dependent Kinase 4
0 references
 
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