Cyclin dependent kinase inhibitor 1C (Q5198257)

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mammalian protein found in Homo sapiens

CDKN1C
cyclin-dependent kinase inhibitor p57
cyclin-dependent kinase inhibitor 1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
p57Kip2

Language	Label	Description	Also known as
English	Cyclin dependent kinase inhibitor 1C	mammalian protein found in Homo sapiens	CDKN1C cyclin-dependent kinase inhibitor p57 cyclin-dependent kinase inhibitor 1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) p57Kip2

Statements

1 reference

13 November 2019

UniProt protein ID

Cyclin-dependent kinase inhibitor 1C

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49918

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

4 references

8 April 2019

Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

8 April 2019

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

8 April 2019

The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

8 April 2019

A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

cyclin-dependent protein serine/threonine kinase inhibitor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

protein-containing complex binding

determination method

1 reference

8 April 2019

Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

determination method

1 reference

8 April 2019

Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

8 April 2019

Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

biological process

positive regulation of transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of protein serine/threonine kinase activity

determination method

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49918&geneProductId=UniProtKB:P49918

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of kinase activity

determination method

1 reference

8 April 2019

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of cyclin-dependent protein kinase activity

determination method

1 reference

8 April 2019

Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of phosphorylation

determination method

1 reference

27 February 2018

CDK inhibitors selectively diminish cell cycle controlled activation of the histone H4 gene promoter by p220NPAT and HiNF-P

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49918&geneProductId=UniProtKB:P49918

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

skeletal system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

kidney development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

placenta development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

regulation of exit from mitosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

myeloid cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

adrenal gland development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

multicellular organism growth

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

neuron maturation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

camera-type eye development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

negative regulation of cyclin-dependent protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

digestive system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

uterus development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

embryonic placenta morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

genetic imprinting

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

regulation of lens fiber cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49918

determination method

Gene Atlas image

PBB GE CDKN1C 213348 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P49918

1 reference

Identifiers.org

Identifiers

MeSH descriptor ID

subject named as

Cyclin-Dependent Kinase Inhibitor p57

0 references

D12.644.360.225.700

0 references

D12.776.167.187.700

0 references

D12.776.476.225.700

0 references

D12.776.624.776.355.700

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000411257

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411257

ENSP00000411552

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411552

ENSP00000413720

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413720

ENSP00000488786

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000488786

ENSP00000484462

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484462

ENSP00000370101

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370101

ENSP00000488761

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000488761

ENSP00000321019

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000321019

ENSP00000496631

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496631

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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