Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation. (Q52039099)

20 April 2018

title

Why does SOD overexpression sometimes enhance, sometimes decrease, hydrogen peroxide production? A minimalist explanation. (English)

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20 April 2018

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1

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20 April 2018

author name string

Armindo Salvador

series ordinal

2

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20 April 2018

Pedro Moradas-Ferreira

series ordinal

3

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20 April 2018

publication date

1 June 2002

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20 April 2018

Free Radical Biology and Medicine

published in

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20 April 2018

volume

32

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20 April 2018

issue

12

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20 April 2018

page(s)

1351-1357

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20 April 2018

Paraquat-mediated selection for mutations in the manganese-superoxide dismutase gene sodA.

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Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the AP-1-mediated induction of matrix-degrading metalloprotease-1

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Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2)

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Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide.

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Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

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Inactivation of dehydratase [4Fe-4S] clusters and disruption of iron homeostasis upon cell exposure to peroxynitrite.

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Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis

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Generating, partitioning, targeting and functioning of superoxide in mitochondria

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7 January 2021

Superoxide activates mitochondrial uncoupling proteins

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7 January 2021

Oxidants as stimulators of signal transduction

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7 January 2021

Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation

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7 January 2021

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Identifiers

DOI

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20 April 2018

PubMed ID

12057773

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20 April 2018