Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. (Q52137761)

22 April 2018

title

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. (English)

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22 April 2018

author name string

Q Gong

1

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22 April 2018

A M Cheng

2

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22 April 2018

A M Akk

3

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22 April 2018

J Alberola-Ila

4

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22 April 2018

G Gong

5

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22 April 2018

T Pawson

6

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22 April 2018

A C Chan

7

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22 April 2018

language of work or name

English

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publication date

1 January 2001

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22 April 2018

published in

Nature Immunology

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22 April 2018

volume

2

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22 April 2018

issue

1

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22 April 2018

page(s)

29-36

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22 April 2018

Integration of T cell receptor-dependent signaling pathways by adapter proteins

cites work

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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 January 2018

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Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

21 January 2018

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

1 reference

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

21 January 2018

1 reference

21 January 2018

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GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

21 January 2018

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The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling

21 January 2018

1 reference

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

21 January 2018

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

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p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.

21 January 2018

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

21 January 2018

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

21 January 2018

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Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes

21 January 2018

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Selection of the T cell repertoire.

21 January 2018

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Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

21 January 2018

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ITAM multiplicity and thymocyte selection: how low can you go?

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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Selective requirement for MAP kinase activation in thymocyte differentiation

21 January 2018

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Positive and negative selection invoke distinct signaling pathways.

21 January 2018

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

21 January 2018

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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

21 January 2018

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Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

21 January 2018

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JNK is required for effector T-cell function but not for T-cell activation

21 January 2018

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Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

21 January 2018

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JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

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Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation

21 January 2018

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Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

21 January 2018

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

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A role for Fas in negative selection of thymocytes in vivo

21 January 2018

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Negative selection in the thymus includes semimature T cells

21 January 2018

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

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Cell cycle-dependent activation of Ras.

21 January 2018

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Ras regulation and function in lymphocytes.

21 January 2018

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The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

21 January 2018

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Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by

21 January 2018

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

21 January 2018

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Tec family kinases in lymphocyte signaling and function

21 January 2018

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Signal transduction in T lymphocytes using a conditional allele of Sos

21 January 2018

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Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

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Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor

21 January 2018

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HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.

21 January 2018

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Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin

21 January 2018

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

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Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

21 January 2018

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Defective T Cell Differentiation in the Absence of Jnk1

21 January 2018

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Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

21 January 2018

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p21ras mediates control of IL-2 gene promoter function in T cell activation.

21 January 2018

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7 January 2021

Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

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7 January 2021

Raf regulates positive selection

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7 January 2021

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

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7 January 2021

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

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7 January 2021

Identifiers

DOI

10.1038/83134

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22 April 2018

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22 April 2018