Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. (Q52167088)

26 April 2018

title

Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. (English)

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26 April 2018

author name string

Bender MA

1

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26 April 2018

Bulger M

2

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26 April 2018

Close J

3

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26 April 2018

Groudine M

4

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26 April 2018

publication date

1 February 2000

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26 April 2018

published in

Molecular Cell

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26 April 2018

volume

5

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26 April 2018

issue

2

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26 April 2018

page(s)

387-393

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26 April 2018

Participation of the human beta-globin locus control region in initiation of DNA replication

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Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes

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Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

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Nucleosome disruption precedes transcription and is largely limited to the transcribed domain of globin genes in murine erythroleukemia cells.

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A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia

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Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy

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Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites

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The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

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Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

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A developmentally stable chromatin structure in the human beta-globin gene cluster

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A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

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Activation by locus control regions?

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Do LCRs open chromatin domains?

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Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation

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Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

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The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells

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Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus

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A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice

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7 January 2021

Knockout-transgenic mouse model of sickle cell disease

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7 January 2021

Gene expression in murine erythroleukemia cells. Transcriptional control and chromatin structure of the alpha 1-globin gene

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7 January 2021

Gamma delta beta-thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human beta-globin cluster

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7 January 2021

The "beta-like-globin" gene domain in human erythroid cells

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7 January 2021

A mouse model for beta 0-thalassemia

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7 January 2021

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Identifiers

DOI

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26 April 2018

PubMed ID

10882079

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26 April 2018