Fourth-generation model for corticosteroid pharmacodynamics: a model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. (Q52220315)

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scientific article published in June 1998

Language	Label	Description	Also known as
English	Fourth-generation model for corticosteroid pharmacodynamics: a model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver.	scientific article published in June 1998

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

Fourth-generation model for corticosteroid pharmacodynamics: a model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

methylprednisolone

1 reference

based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

inferred from title

author name string

Sun YN

1

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

DuBois DC

2

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

Almon RR

3

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

Jusko WJ

4

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

publication date

1 June 1998

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

Journal of Pharmacokinetics and Pharmacodynamics

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Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

26

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Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

3

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

289-317

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of glucocorticoid receptor protein and mRNA levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated methylprednisolone pharmacodynamics in rats: steroid-induced receptor down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prednisone side-effects and serum-protein levels. A collaborative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of glucocorticoid receptor and induction of tyrosine aminotransferase in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticosteroid receptor dimerization investigated by analysis of receptor binding to glucocorticosteroid responsive elements using a monomer-dimer equilibrium model

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologous down regulation of the glucocorticoid receptor: the molecular machinery.

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https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

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Dose dependent pharmacokinetics of prednisone and prednisolone in man

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https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

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Pharmacoimmunodynamics of methylprednisolone: trafficking of helper T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extended least squares nonlinear regression: a possible solution to the "choice of weights" problem in analysis of individual pharmacokinetic data

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

6 alpha-Methylprednisolone and 6 alpha-methylprednisone plasma protein binding in humans and rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover of skeletal muscle contractile proteins in glucocorticoid myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro RNA synthesis with SP6 RNA polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation and phosphorylation of glucocorticoid receptors in cultured cells. Investigations with a monospecific antiserum against a bacterially expressed receptor fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molar quantification of specific messenger ribonucleic acid expression in northern hybridization using cRNA standards

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an AUUUA-specific messenger RNA binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamic model for joint exogenous and endogenous corticosteroid suppression of lymphocyte trafficking

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacodynamic modeling of cortisol suppression from fluocortolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noncompartmental Determination of the Steady‐State Volume of Distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second generation model for prednisolone pharmacodynamics in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two-compartment basophil cell trafficking model for methylprednisolone pharmacodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

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Comparison of four basic models of indirect pharmacodynamic responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of glucocorticoid receptor phosphorylation in intact cells. Evidence for hormone-induced hyperphosphorylation after activation and recycling of hyperphosphorylated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Third-generation model for corticosteroid pharmacodynamics: roles of glucocorticoid receptor mRNA and tyrosine aminotransferase mRNA in rat liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of hepatic tyrosine aminotransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid-receptor complexes in rat thymus cells. Rapid kinetic behavior and a cyclic model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated pharmacodynamics of prednisolone in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mRNA and protein stability in gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of glucocorticoid unresponsive cell variants using a mouse glucocorticoid receptor complementary DNA clone

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated prednisolone pharmacodynamics in rats: model verification using a dose-sparing regimen

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of tissue delivery and receptor occupancy of methylprednisolone in rats by a liposomal formulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies to the rat liver glucocorticoid receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

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The effects of androgen administration on phallic androgen receptor expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylprednisolone disposition in rabbits. Analysis, prodrug conversion, reversible metabolism, and comparison with man

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluid Shifts and Other Factors Affecting Plasma Protein Binding of Prednisolone by Equilibrium Dialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression of heat shock proteins 70 and 90: potential implication for differential sensitivity of tissues to glucocorticoids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential dynamics of receptor down-regulation and tyrosine aminotransferase induction following glucocorticoid treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mRNA stability and its relevance to disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10098101

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1023233409550

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 April 2018

http://europepmc.org/abstract/MED/10098101

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