Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling. (Q52240608)

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12 November 2019

title

Morphine-3-glucuronide has a minor effect on morphine antinociception. Pharmacodynamic modeling (English)

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12 November 2019

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3

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12 November 2019

author name string

Gardmark M

series ordinal

1

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12 November 2019

Karlsson MO

series ordinal

2

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12 November 2019

Hammarlund-Udenaes M

series ordinal

4

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12 November 2019

language of work or name

English

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publication date

1 July 1998

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Journal of Pharmaceutical Sciences

12 November 2019

published in

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12 November 2019

volume

87

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12 November 2019

issue

7

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12 November 2019

page(s)

813-820

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Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat

12 November 2019

cites work

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7 January 2021

Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine

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Relationship between morphine analgesia and cortical extracellular fluid levels of morphine and its metabolites in the rat: a microdialysis study

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Morphine-3-glucuronide--a potent antagonist of morphine analgesia

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Intrathecal morphine-3-glucuronide does not antagonize spinal antinociception by morphine or morphine-6-glucuronide in rats.

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Lack of effect of morphine-3-glucuronide on the spinal antinociceptive actions of morphine in the rat: an electrophysiological study.

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Morphine-3-glucuronide: silent regulator of morphine actions.

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Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity

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7 January 2021

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide

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7 January 2021

The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex.

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Influence of renal function on the elimination of morphine and morphine glucuronides.

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Morphine-6-glucuronide, a potent mu agonist.

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Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position

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Morphine-6-glucuronide has high affinity for the opioid receptor

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Analgesic Effect of Morphine Glucuronides

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The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme

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Species differences in metabolism of codeine: urinary excretion of codeine glucuronide, morphine-3-glucuronide and morphine-6-glucuronide in mice, rats, guinea pigs and rabbits

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Species difference of site-selective glucuronidation of morphine

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Acute tolerance in morphine analgesia: continuous infusion and single injection in rats

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Acute tolerance to narcotic analgesic drugs in rats

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Differential development of acute tolerance to analgesia, respiratory depression, gastrointestinal transit and hormone release in a morphine infusion model

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Ventilatory effects of fourth cerebroventricular infusions of morphine-6- or morphine-3-glucuronide in the awake dog

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A pharmacokinetic-pharmacodynamic model of tolerance to morphine analgesia during infusion in rats

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An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites

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7 January 2021

Determination of morphine in serum and cerebrospinal fluid by gas chromatography and selected ion monitoring after reversed-phase column extraction

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The Effects of Caffeine and Theophylline on Nociceptive Stimulation in the Rat

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A MOLECULAR BASIS FOR DRUG ACTION.

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Comparison of four basic models of indirect pharmacodynamic responses

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Physiologic indirect response models characterize diverse types of pharmacodynamic effects

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Mu receptor binding of some commonly used opioids and their metabolites

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Pharmacology of morphine and morphine-3-glucuronide at opioid, excitatory amino acid, GABA and glycine binding sites

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Intrathecal high dose morphine produces hyperalgesia in the rat

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Effects of morphine-3-glucuronide and morphine on the K+-evoked release of [3H]-glutamic acid and [14C]-gamma-aminobutyric acid from rat brain synaptosomes

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7 January 2021

Hot plate versus tail flick: evaluation of acute tolerance to continuous morphine infusion in the rat model

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Oral morphine in cancer pain: influences on morphine and metabolite concentration

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Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations

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Concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide in serum and cerebrospinal fluid following morphine administration to patients with morphine-resistant pain.

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Plasma and cerebrospinal fluid concentrations of morphine and morphine glucuronides after oral morphine. The influence of renal failure.

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Kinetics of morphine in patients with renal failure

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The pharmacokinetics of morphine and morphine glucuronides in kidney failure

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Morphine and morphine metabolite concentrations in cerebrospinal fluid and plasma in cancer pain patients after slow-release oral morphine administration

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7 January 2021

Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine

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7 January 2021

Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists

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7 January 2021

Identifiers

DOI

10.1021/JS980056F

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12 November 2019

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