Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. (Q52534683)

2 May 2018

title

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. (English)

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author name string

Gerth UC

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Price DA

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Purbhoo MA

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Boulter JM

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Gao GF

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Bell JI

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Phillips RE

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Jakobsen BK

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language of work or name

English

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publication date

1 April 1999

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2 May 2018

published in

Nature Medicine

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volume

5

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issue

4

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page(s)

399-404

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Antigen recognition by class I-restricted T lymphocytes

cites work

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T cells and viral infections

21 January 2018

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Role of the major histocompatibility complex class I antigens in tumor growth and metastasis

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Effector mechanisms in allograft rejection

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CD8 is needed for development of cytotoxic T cells but not helper T cells

21 January 2018

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Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells

21 January 2018

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The CD8 coreceptor revisited: one chain good, two chains better

21 January 2018

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Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

21 January 2018

1 reference

T cell receptor and CD8-dependent tyrosine phosphorylation events in cytotoxic T lymphocytes: activation of p56lck by CD8 binding to class I protein

21 January 2018

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Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 January 2018

1 reference

Is CD8 dependence a true reflection of TCR affinity for antigen?

21 January 2018

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Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

21 January 2018

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Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

21 January 2018

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Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events

21 January 2018

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Cell-cell adhesion mediated by CD8 and MHC class I molecules

21 January 2018

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Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

21 January 2018

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A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.

21 January 2018

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Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule

21 January 2018

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CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

21 January 2018

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CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

21 January 2018

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

21 January 2018

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

21 January 2018

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Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

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Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides.

21 January 2018

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Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

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Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

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Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors

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Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.

21 January 2018

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T cell activation determined by T cell receptor number and tunable thresholds.

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A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

21 January 2018

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Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative

21 January 2018

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CD4 augments the response of a T cell to agonist but not to antagonist ligands

21 January 2018

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Ligand recognition by alpha beta T cell receptors

21 January 2018

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Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]

21 January 2018

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A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing

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Soluble CD8 levels in the CSF and serum of patients with multiple sclerosis

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Increased levels of soluble CD8 molecule in the serum of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related disorders.

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The differentiation and function of human T lymphocytes

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Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes

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Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies

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Participation of CD4 coreceptor molecules in T-cell repertoire selection

21 January 2018

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The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection

21 January 2018

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21 January 2018

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CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

21 January 2018

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7 January 2021

Disruption of CD8-dependent negative and positive selection of thymocytes is correlated with a decreased association between CD8 and the protein tyrosine kinase, p56lck

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7 January 2021

Phosphorylation of murine CD8α is not essential for responses of T cell hybridomas to antigen

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7 January 2021

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association

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7 January 2021

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

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7 January 2021

CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68. 1

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7 January 2021

A structure-based approach to designing synthetic CD8alpha peptides that can inhibit cytotoxic T-lymphocyte responses

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7 January 2021

Soluble interleukin-2 receptor and soluble CD8 antigen in active rheumatoid arthritis

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7 January 2021

Identifiers

DOI

10.1038/7398

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2 May 2018

Dimensions Publication ID

1031549960

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2 May 2018