Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. (Q52575181)

3 May 2018

title

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. (English)

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3 May 2018

polycystic kidney disease

main subject

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Nikolay O Bukanov

1

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3 May 2018

Laurie A Smith

2

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3 May 2018

Katherine W Klinger

3

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3 May 2018

Steven R Ledbetter

4

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3 May 2018

Oxana Ibraghimov-Beskrovnaya

5

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3 May 2018

language of work or name

English

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publication date

22 November 2006

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3 May 2018

published in

Nature

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3 May 2018

volume

444

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3 May 2018

issue

7121

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3 May 2018

page(s)

949-952

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3 May 2018

Hypertension and left ventricular hypertrophy in autosomal dominant polycystic kidney disease

cites work

1 reference

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Polycystic kidney disease: new understanding in the pathogenesis

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The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

21 January 2018

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

21 January 2018

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PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

21 January 2018

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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

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Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.

21 January 2018

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Cilium-generated signaling and cilia-related disorders

21 January 2018

1 reference

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PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

21 January 2018

1 reference

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Cilia and the cell cycle?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05348

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

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Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

21 January 2018

1 reference

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Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease.

21 January 2018

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

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Roscovitine targets, protein kinases and pyridoxal kinase

21 January 2018

1 reference

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p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death

21 January 2018

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Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease

21 January 2018

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Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

21 January 2018

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Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanism.

21 January 2018

1 reference

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Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo

21 January 2018

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Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability

21 January 2018

1 reference

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Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

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Taxol inhibits progression of congenital polycystic kidney disease

21 January 2018

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In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

21 January 2018

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7 January 2021

Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05348

7 January 2021

Caspases, Bcl-2 proteins and apoptosis in autosomal-dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05348

7 January 2021

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05348

7 January 2021

Identifiers

DOI

10.1038/NATURE05348

1 reference

3 May 2018

Dimensions Publication ID

1009939406

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3 May 2018