A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. (Q52677435)

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scientific article published in March 2007

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English	A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.	scientific article published in March 2007

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scholarly article

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26 December 2019

A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes (English)

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26 December 2019

spinocerebellar ataxia

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Giovanni Stevanin

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26 December 2019

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Morwena Latouche

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26 December 2019

Christelle Lasbleiz

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26 December 2019

Elodie Martin

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26 December 2019

Véronique Monnier

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26 December 2019

Thomas Debeir

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26 December 2019

Annick Mouatt-Prigent

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26 December 2019

Marie-Paule Muriel

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26 December 2019

Lydie Morel

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26 December 2019

Merle Ruberg

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26 December 2019

Alexis Brice

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1 March 2007

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26 December 2019

Journal of Neuroscience

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26 December 2019

2483-2492

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26 December 2019

10

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26 December 2019

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Formation of polyglutamine inclusions in non-CNS tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

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Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levodopa induces a cytoplasmic localization of D1 dopamine receptors in striatal neurons in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic suppression of polyglutamine toxicity in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine repeats and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of genes that modify ataxin-1-induced neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of ataxin-7 in normal human brain and retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A conditional tissue-specific transgene expression system using inducible GAL4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Two populations of neuronal intranuclear inclusions in SCA7 differ in size and promyelocytic leukaemia protein content

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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A Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

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Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic modifiers of tauopathy in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An integrative approach to gain insights into the cellular function of human ataxin-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TATA-binding protein in neurodegenerative disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for both wild-type and expanded ataxin-7 in transcriptional regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diseases of unstable repeat expansion: mechanisms and common principles

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine and polyalanine expansions in ataxin7 result in different types of aggregation and levels of toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid cloning of expanded trinucleotide repeat sequences from genomic DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344386

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5453-06.2007

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26 December 2019

1 reference

Europe PubMed Central

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26 December 2019

1 reference

Europe PubMed Central

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26 December 2019

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