Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. (Q52956152)

9 May 2018

title

Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. (English)

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9 May 2018

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8

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Kari Hemminki

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object named as

Kari Hemminki

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Gunnar Steineck

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Charlotta Ryk

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Ismail Hosen

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P Sivaramakrishna Rachakonda

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Barbara Heidenreich

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Petra J de Verdier

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language of work or name

English

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publication date

7 April 2015

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International Journal of Cancer

published in

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volume

137

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issue

7

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page(s)

1621-1629

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Epidemiology and risk factors of urothelial bladder cancer

cites work

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A cell of origin gene signature indicates human bladder cancer has distinct cellular progenitors

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Follow-up procedures for non-muscle-invasive bladder cancer: an update

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Bladder cancer: translating molecular genetic insights into clinical practice

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Comprehensive molecular characterization of urothelial bladder carcinoma

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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

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Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.

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Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer

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Mutational context and diverse clonal development in early and late bladder cancer.

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Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer

21 January 2018

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TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

21 January 2018

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Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome

21 January 2018

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Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine

21 January 2018

1 reference

Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: a genomic and molecular study

21 January 2018

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TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine

21 January 2018

1 reference

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

21 January 2018

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It all comes together at the ends: telomerase structure, function, and biogenesis

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Hallmarks of Cancer: The Next Generation

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Telomerase: central regulator of all of the hallmarks of cancer

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Human telomerase expression regulation

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TERT promoter mutations in familial and sporadic melanoma

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High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

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Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma.

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Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

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TERT promoter mutations in cancer development

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The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

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BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence

21 January 2018

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Telomere length measurement by a novel monochrome multiplex quantitative PCR method

21 January 2018

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A prospective study of telomere length measured by monochrome multiplex quantitative PCR and risk of lung cancer

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Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.

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Novel anticancer therapeutics targeting telomerase

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Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc.

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Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter--effect on telomerase expression and telomere length maintenance in non-small cell lung cancer.

21 January 2018

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Telomeres and cancer: from crisis to stability to crisis to stability

21 January 2018

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Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice

21 January 2018

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FGFR3 stimulates stearoyl CoA desaturase 1 activity to promote bladder tumor growth

21 January 2018

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Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation

21 January 2018

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Distinguishing nested variants of urothelial carcinoma from benign mimickers by TERT promoter mutation.

21 January 2018

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Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases

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Separation of telomerase functions by reverse genetics

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A Population-based Study of 538 Patients with Newly Detected Urinary Bladder Neoplasms Followed during 5 Years

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21 January 2018

Identifiers

DOI

10.1002/IJC.29526

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9 May 2018

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9 May 2018